Understanding the Applicability and Limitations of In Silico and In Vitro Safety Models Towards the Design and Selection of the Safest Drug Candidates

The second webinar in this series on New Approaches in Toxicology was presented by Takafumi Takai PhD from Takeda.

About the Webinar

A variety of in silico and in vitro safety assays are widely used in lead optimization in order to capture the safety-related liability as early as possible. Understanding the applicability and limitation of each assay based on the chemical space/chemotype is important for the effective usage. Several case studies of the applicability analysis including in silico phototoxicity prediction and low-dose in vivo toxicity prediction by cytotoxicity assay will be presented.

About the Speaker

Takafumi Takai PhD Senior Scientist | Takeda Takafumi has more than 15 years of industry experience in drug discovery. He currently manages safety assessments mainly during compound optimization at Takeda California by using his expertise in medicinal and computational chemistry. Prior to joining the drug safety department, he led drug discovery projects as a medicinal chemist at Takeda in Japan. He holds a Ph.D. from Okayama University, Japan as well as a Master’s Degree from Tohoku University, Japan.

Watch the webinar to learn more!

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