---
title: Determining Chromatographic Hydrophobicity Index using LC-TOF
description: Read our poster. Determining Chromatographic Hydrophobicity Index using LC-TOF. Contact Evotec to learn more!
image: https://news.cyprotex.com/hubfs/Sciencepool/Sciencepool%20images/Shutterstock%20images/shutterstock_691546522-lab-white-05-science-pool.jpg
---

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# Science Pool

# Determining Chromatographic Hydrophobicity Index using LC-TOF

Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Aug 11, 2021 3:27:50 PM

Lipophilicity is an essential physicochemical property used to predict compound behaviour with respect to pharmacokinetics, pharmacodynamics and safety. 

In this poster, we focus on:

- the use of the chromatographic hydropobicity index (CHI) as an alternative to LogD for lipophilicity determination
- the use of LC Time-of-Flight mass spectrometry for CHI determination and its advantages with respect to reduced inference from impurities, decreased compound requirements and improved throughput
- applicability of CHI for large scale screening projects
- the presentation of the reproducibility and robustness of the method along with comparison with literature values

Read our poster to learn more about our research!

[LEARN MORE](https://news.cyprotex.com/hubfs/Sciencepool/Posters/Cyprotex%20posters/chi-using-lc-tof-ht-adme2021.pdf)

 

 

 

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