Mitochondria are a common target for drug-induced toxicity. Several different in vitro methods exist for investigating drug-induced mitochondrial toxicity.
In this poster, we focus on:
- a comparison of three different in vitro assays for detecting mitochondrial toxicity (Glu/Gal cytotoxicity assay, Seahorse Flux Analyser and high content imaging of mitochondrial membrane potential)
- the effect of protein binding on the mitochondrial toxicity
- recommendations for a tiered screening approach
Read our poster to learn more about our research!