---
title: DILI Prediction using Human 3D Models, HCS and Concentration Normalisation
description: Read our poster. DILI Prediction using Human 3D Microtisue Model and Concentration Normalisation. Contact Evotec to learn more!
image: https://news.cyprotex.com/hubfs/Sciencepool/Sciencepool%20images/Shutterstock%20images/shutterstock_1118711141-liver-red-02-science-pool.jpg
---

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# Science Pool

# DILI Prediction using Human 3D Models, HCS and Concentration Normalisation

Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Feb 11, 2021 7:48:54 PM

*In vitro* 3D cell-based models are more representative of the complex *in vivo* microenvironment than traditional 2D monolayers. Furthermore, these models allow for long term compound exposures - more closely replicating clinical dosing strategies.

In this poster, we focus on:

- 3D human liver microtissues formed from multiple donors co-cultured with human non-parenchymal cells
- exposure of the cells to multiple doses of hepatotoxins and non-hepatotoxins
- HCS analysis of DNA structure, GSH content, ROS formation and mitochondrial function
- the impact of correcting for therapeutically relevant tissue Cmax 

Read our poster to learn more about our research!

[LEARN MORE](https://news.cyprotex.com/hubfs/Sciencepool/Posters/Cyprotex%20posters/Dili-prediction-human-3d-hcs-sot2017.pdf)

 

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