In vitro 3D cell-based models are more representative of the complex in vivo microenvironment than traditional 2D monolayers. Furthermore, these models allow for long term compound exposures - more closely replicating clinical dosing strategies.
In this poster, we focus on:
- 3D human liver microtissues formed from multiple donors co-cultured with human non-parenchymal cells
- exposure of the cells to multiple doses of hepatotoxins and non-hepatotoxins
- HCS analysis of DNA structure, GSH content, ROS formation and mitochondrial function
- the impact of correcting for therapeutically relevant tissue Cmax
Read our poster to learn more about our research!