The mitochondria are a common target of drug-induced toxicity. A number of approaches are used to detect mitochondrial toxicity but how do we know which to use?
In this poster, we focus on:
- a comparison of the different methods including the glucose/galactose (glu/gal) cytotoxicity assay, high content screening (HCS) method for mitochondrial membrane potential and cytotoxicity, and the Seahorse flux analyser
- the ability of the different methods to predict mitochondrial toxicity through sensitivity, specificity and accuracy assessment
- an insight into the mechanism of mitochondrial toxicity through the Seahorse flux analyser and permeabilised cell assay.
Read our poster to learn more about our research!