---
title: Inhibitor Preincubation Time on Human OATP1B1, P-gp and BCRP
description: Read our poster. Effect of Inhibitor Preincubation on Human OATP1B1, P-gp and BCRP. Contact Evotec to learn more!
image: https://news.cyprotex.com/hubfs/Sciencepool/Sciencepool%20images/Shutterstock%20images/shutterstock_1679447359-transporters-blue-02-science-pool.jpg
---

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# Science Pool

# Inhibitor Preincubation Time on Human OATP1B1, P-gp and BCRP

Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Feb 11, 2021 8:44:00 PM

Pre-incubating with inhibitor can influence inhibitory potency for some drug transporters such as OATP1B1. It is thought that this phenomenon is a consequence of the time taken for some inhibitors to accumulate inside the cell.

In this poster, we focus on:

- a comparison of a 30 min pre-incubation time with a 15 min pre-incubation time for OATP1B1
- the impact of inhibitor pre-incubation on P-gp and BCRP inhibition in a polarised cell monolayer

Read our poster to learn more about our research!

[LEARN MORE](https://news.cyprotex.com/hubfs/Sciencepool/Posters/Cyprotex%20posters/inhibitor-preincubation-oatp1b1-pgp-bcrp-ddi2018.pdf)

 

 

 

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