Pre-incubating with inhibitor can influence inhibitory potency for some drug transporters such as OATP1B1. It is thought that this phenomenon is a consequence of the time taken for some inhibitors to accumulate inside the cell.
In this poster, we focus on:
- a comparison of a 30 min pre-incubation time with a 15 min pre-incubation time for OATP1B1
- the impact of inhibitor pre-incubation on P-gp and BCRP inhibition in a polarised cell monolayer
Read our poster to learn more about our research!