---
title: Application of a Low Intrinsic Clearance Assay in Drug Discovery
description: Read our poster. Application of Low Intrinsic Clearance Assay in Preclinical Drug Discovery. Contact Evotec to learn more!
image: https://news.cyprotex.com/hubfs/Sciencepool/Sciencepool%20images/Shutterstock%20images/shutterstock_403792816-lab-white-01-science-pool.jpg
---

[![Cyprotex | The Leading ADME-Tox Specialist](https://news.cyprotex.com/hs-fs/hubfs/cyprotex%20logo.png?width=224&height=62&name=cyprotex%20logo.png "Cyprotex | The Leading ADME-Tox Specialist")](https://www.cyprotex.com/)

# Science Pool

# Application of a Low Intrinsic Clearance Assay in Drug Discovery

Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Feb 12, 2021 3:50:55 PM

In order to accurately predict human pharmacokinetics and efficacious dose, a robust measurements of clearance is essential.

In this poster, we focus on:

- a novel primary human hepatocyte media supplement (HepExtendTM)
- a comparison of HepExtendTM with the widely used CM4000 with and without a Geltrex overlay
- a correlation of scaled* in vitro* human intrinsic clearance with* in vivo* human intrinsic clearance

Read our poster to learn more about our research!

[LEARN MORE](https://news.cyprotex.com/hubfs/Sciencepool/Posters/Cyprotex%20posters/preclinical-low-intrinsic-clearance-assay-issx2017.pdf)

 

 

 

 Tags: [Posters](https://news.cyprotex.com/sciencepool/tag/posters), [ADME/DMPK](https://news.cyprotex.com/sciencepool/tag/adme-dmpk)