---
title: Comparison of MEA and Neurite Outgrowth for Determining CNS Liability
description: Read our poster.  Comparison of MEA and Neurite Outgrowth for Detecting CNS Liability. Contact Evotec to learn more!
image: https://news.cyprotex.com/hubfs/Sciencepool/Sciencepool%20images/Shutterstock%20images/shutterstock_336721292-neuron-blue-02-science-pool.jpg
---

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# Science Pool

# Comparison of MEA and Neurite Outgrowth for Determining CNS Liability

Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Feb 12, 2021 2:20:57 PM

Domoic acid is a neurotoxin which was associated with the poisoning of 107 people and 3 subsequent deaths on Prince Edward Island in 1987 following the ingestion of mussels containing this poison. The associated neurotoxic effects of domoic acid are clearly identified at concentrations of ≥ 1µM using neurons analysed on a microelectrode array (MEA) platform. Interestingly, domoic acid had no effect up to 25µM in the neurite outgrowth assay (another common method for detecting neurotoxicity).

In this poster, we focus on:

- a comparison of the neurite outgrowth assay with the MEA platform
- sensitivity of the two methods for detecting neurotoxins and seizurogenic compounds
- a screening strategy for testing neurotoxic compounds 

Read our poster to learn more about our research!

[LEARN MORE](https://news.cyprotex.com/hubfs/Sciencepool/Posters/Cyprotex%20posters/Mea-vs-neurite-outgrowth-CNS-liability-sot2020.pdf)

 

 

 

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