Drug-induced mitochondrial toxicity has been implicated in adverse events such as liver failure and cardiotoxicity. There are several in vitro assays used to detect mitochondrial toxicity including the glu/gal cytotoxicity assay, high content screening for mitochondrial membrane potential and the Seahorse flux analyser to detect OCR (cellular oxygen consumption rate), reserve capacity and ECAR (extracellular acidification rate).
In this poster, we focus on:
- an analysis of the different methods for detecting mitochondrial toxicity
- an insight into the mechanism of mitochondrial toxicity using the permeabilised cell assay.
Read our poster to learn more about our research!