---
title: Strategies in In Vitro Mitochondrial Toxicity Assessment
description: Read our poster. In Vitro Mechanistic Understanding of Mitochondrial Toxicity. Contact Evotec to learn more!
image: https://news.cyprotex.com/hubfs/Sciencepool/Sciencepool%20images/Shutterstock%20images/shutterstock_708495556-mitochondria-green-01-science-pool.jpg
---

[![Cyprotex | The Leading ADME-Tox Specialist](https://news.cyprotex.com/hs-fs/hubfs/cyprotex%20logo.png?width=224&height=62&name=cyprotex%20logo.png "Cyprotex | The Leading ADME-Tox Specialist")](https://www.cyprotex.com/)

# Science Pool

# Strategies in In Vitro Mitochondrial Toxicity Assessment

Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Feb 12, 2021 2:26:34 PM

Drug-induced mitochondrial toxicity has been implicated in adverse events such as liver failure and cardiotoxicity. There are several *in vitro* assays used to detect mitochondrial toxicity including the glu/gal cytotoxicity assay, high content screening for mitochondrial membrane potential and the Seahorse flux analyser to detect OCR (cellular oxygen consumption rate), reserve capacity and ECAR (extracellular acidification rate).

In this poster, we focus on:

- an analysis of the different methods for detecting mitochondrial toxicity
- an insight into the mechanism of mitochondrial toxicity using the permeabilised cell assay. 

Read our poster to learn more about our research!

[LEARN MORE](https://news.cyprotex.com/hubfs/Sciencepool/Posters/Cyprotex%20posters/Mechanistic-mitochondrial-toxicity-invitro-eurotox2019.pdf)

 

 

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