The benefits of 3D cell-based models in the prediction of drug-induced liver injury are now being realised.
In this poster, we focus on:
- the use of 3D models (cryopreserved human hepatocytes co-cultured with human non-parenchymal cells compared with HepaRG monocultures)
- cytochrome P450 (CYP) activity in the different models
- HCS analysis of DNA structure, GSH content, ROS formation and mitochondrial function
- prediction of DILI potential for a set of DILI-positive and negative compounds
Read our poster to learn more about our research!