Pilocarpine is a muscarinic receptor agonist which is used as a model inducer of epilepsy in the rat. We evaluated the seizurogenic response of pilocarpine using an in vitro MEA platform.
In this poster, we focus on:
- a comparison of pilocarpine response in different neuronal cell types; cryopreserved rat cortical neurons, cryopreserved rat hippocampal neurons and a co-culture of human iPSC-derived glutamatergic neurons with astrocytes
- the impact of DIV and cell maturation on the response
- identifying muscarinic receptor expression over time
Read our poster to learn more about our research!