Cardiotoxicity in response to pharmaceutical drugs, chemicals and environmental toxicants can develop as a result of changes in structural integrity of cardiac tissue or functional changes in cardiac electrophysiology. The development of new approach methodologies (NAMs) is important in predicting these cardiotoxic liabilities.
In this poster, we focus on:
- the use of human iPSC-derived cardiomyocytes in combination with a panel of in vitro toxicology assays including:
- calcium transient monitoring
- high content imaging of morphological changes
- cellular ATP assessment
- high throughput transcriptomics using RNA-seq
- the results from profiling 42 compounds in the assessment of structural and functional endpoints along with predictive outcome (sensitivity, specificity and accuracy)
- mechanistic information including the detection of biological pathways associated with the cardiotoxic effects
Read our poster to learn more about our research!