As the CNS is a complex organ system, neurotoxicity can be difficult to assess and detect during preclinical development in animal models.
In this poster, we focus on:
- the use of cell-based models in conjunction with MEA to identify neurogenic and seizurogenic compounds
- a comparison between rat cortical neurons and a co-culture of human iPSC-derived glutamatergic neurons with iPSC-derived astrocytes in their response to known neurotoxic and seizurogenic compounds
- a recommended in vitro screening approach for early detection of neurotoxicity
Read our poster to learn more about our research!