---
title: Strategies to Minimise the Risk of DILI
description: Read our publication on the evolution of strategies to minimise the risk of human DILI. Contact Evotec to learn more!
image: https://news.cyprotex.com/hubfs/Sciencepool/Sciencepool%20images/Shutterstock%20images/shutterstock_1594264243-liver-black-01-science-pool.jpg
---

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# Science Pool

# Strategies to Minimise the Risk of DILI

Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Mar 7, 2021 1:24:04 PM

Drug-induced liver injury (DILI) is a leading cause of drug failure due to poor translation between traditional preclinical animal models and human clinical outcome. More sophisticated human *in vitro* cell-based models with multiparametric endpoints are now being developed to improve DILI prediction.

In this review article, we focus on:

- the evolution of the strategies adopted to improve human hepatotoxicity prediction in drug discovery
- how companies are addressing translational challenges using human relevant cell-based models
- a further insight into the key role of human exposure and hepatic drug uptake transporters (e.g., OATPs, OAT2)

Read our publication to learn more!

[LEARN MORE](https://news.cyprotex.com/hubfs/Sciencepool/Articles,%20DDups%20and%20Whitepapers/strategies-to-minimise-the-risk-of-human-dili-publication.pdf)

 Tags: [Articles & Whitepapers](https://news.cyprotex.com/sciencepool/tag/articles-whitepapers), [Toxicology & Safety](https://news.cyprotex.com/sciencepool/tag/toxicology-safety)