| Articles & Whitepapers (11)

How Proteomics Boosts the Discovery of Novel Drugs and Biomarkers

Posted by Evotec on Mar 8, 2021 10:41:17 PM

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Tags: Articles & Whitepapers, Proteomics, Metabolomics & Biomarkers

Ensuring Bioanalytical Quality in a Highly Automated HT-ADME Laboratory

Posted by Evotec on Mar 7, 2021 2:24:36 PM

The field of high-throughput ADME (HT-ADME) places a greater demand on the analytical systems supplying end point quantification.

In this review, we focus on:

recent technological advances in LC–MS/MS which dramatically reduce sample analysis time
evaluating the impact of reduced sample analysis time on analytical data quality
the use of appropriate LC-MS/MS systems
software tools to aid bioanalytical quality

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Tags: Articles & Whitepapers, ADME/DMPK

Improving the Prediction of Mitochondrial Toxicity

Posted by Evotec on Mar 7, 2021 1:57:23 PM

Drug-induced mitochondrial dysfunction has been associated with organ toxicity and drug withdrawal. Highly specific and sensitive in vitro assays have been developed to predict mitochondrial dysfunction.

In this publication, we focus on:

a background to mitochondrial toxicity
a comparison of the Glu/Gal mitochondrial assay with the Seahorse assay for the prediction of mitochondrial toxicity
how the Seahorse assay provides a mechanistic understanding of mitochondrial toxicity

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Tags: Articles & Whitepapers, Toxicology & Safety

Strategies to Minimise the Risk of DILI

Posted by Evotec on Mar 7, 2021 1:24:04 PM

Drug-induced liver injury (DILI) is a leading cause of drug failure due to poor translation between traditional preclinical animal models and human clinical outcome. More sophisticated human in vitro cell-based models with multiparametric endpoints are now being developed to improve DILI prediction.

In this review article, we focus on:

the evolution of the strategies adopted to improve human hepatotoxicity prediction in drug discovery
how companies are addressing translational challenges using human relevant cell-based models
a further insight into the key role of human exposure and hepatic drug uptake transporters (e.g., OATPs, OAT2)

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Tags: Articles & Whitepapers, Toxicology & Safety

The Future of MEA in Early Toxicology Assessment

Posted by Evotec on Mar 7, 2021 1:11:12 PM

It is almost 50 years since MEA was first developed, however, the power of this technology in toxicology testing has only just been realised due to the introduction of the multi-well MEA allowing for its utility in high throughput
analysis.

In this whitepaper, we focus on:

the current challenges within the pharmaceutical industry in terms of toxicology prediction
how companies are addressing these challenges using human relevant cell-based models
an in-depth evaluation of microelectrode array (MEA) and its key role in in vitro cardiotoxicity and neurotoxicity toxicology testing

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Tags: Neuroscience, Articles & Whitepapers, Toxicology & Safety