| Neuroscience (5)

Rotenone-induced Toxicity in iPSC-derived Neurons

Posted by Evotec on Feb 24, 2021 12:03:26 PM

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Tags: Neuroscience, Posters

Discovery & Characterization of Neuroprotective Compounds Relevant to ALS

Posted by Evotec on Feb 20, 2021 7:30:58 PM

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Tags: Neuroscience, Posters, Hit & Target ID/Validation, In vitro Biology

Motor Neuron Diseases DDup #6

Posted by Evotec on Feb 16, 2021 10:38:14 PM

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Tags: Neuroscience, Articles & Whitepapers

Neurodegenerative Diseases DDup #2

Posted by Evotec on Feb 16, 2021 10:31:50 PM

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Tags: Neuroscience, Articles & Whitepapers

Evaluating Pharmacology and Neurotoxicity using MEA

Posted by Evotec on Feb 12, 2021 3:46:13 PM

Advances in human iPSC-derived neuronal models in conjunction with microelectrode array (MEA) technology has enhanced our understanding of complex burst organisation and network characteristics in humans. This now provides a viable human model for studying drug-induced toxicity and CNS liabilities as well as potential pharmacology effects on the neurones.

In this poster, we focus on:

investigating co-cultures of human iPSC-derived glutamatergic neurons with astrocytes on the MEA platform
determining spike activity, burst organisation and network organisation (synchrony) patterns for different types of CNS compounds (GABA_A agonists, potassium channel blockers, opioid receptor agonist, glycine receptor antagonist and cholinergic and muscarinic receptor agonists)
understanding developmental and pharmacological responses when assessed by MEA

Read our poster to learn more about our research!

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Tags: Neuroscience, Posters, Toxicology & Safety