| Neuroscience (5)

Neurodegenerative Diseases DDup #2

Posted by Evotec on Feb 16, 2021 10:31:50 PM

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Tags: Neuroscience, Articles & Whitepapers

Evaluating Pharmacology and Neurotoxicity using MEA

Posted by Evotec on Feb 12, 2021 3:46:13 PM

Advances in human iPSC-derived neuronal models in conjunction with microelectrode array (MEA) technology has enhanced our understanding of complex burst organisation and network characteristics in humans. This now provides a viable human model for studying drug-induced toxicity and CNS liabilities as well as potential pharmacology effects on the neurones.

In this poster, we focus on:

investigating co-cultures of human iPSC-derived glutamatergic neurons with astrocytes on the MEA platform
determining spike activity, burst organisation and network organisation (synchrony) patterns for different types of CNS compounds (GABA_A agonists, potassium channel blockers, opioid receptor agonist, glycine receptor antagonist and cholinergic and muscarinic receptor agonists)
understanding developmental and pharmacological responses when assessed by MEA

Read our poster to learn more about our research!

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Tags: Neuroscience, Posters, Toxicology & Safety

Proteome Analysis of Huntington's Disease Fact Sheet

Posted by Evotec on Feb 12, 2021 2:05:00 PM

Download this fact sheet to learn more about Huntington's Disease proteome base including:

Strains and collection of tissues
Deep proteome workflow
Key findings in brain tissues and liver

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Tags: Neuroscience, Fact Sheets

Huntingtin (HTT) Quantitation Assays Fact Sheet

Posted by Evotec on Feb 11, 2021 10:37:59 AM

Download this fact sheet to learn more about Huntingtin quantitation assays including:

Immunoassay platforms
HTT assay menu
Case studies

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Tags: Neuroscience, Fact Sheets

Huntingtons Disease AAV and LV Capabilities Fact Sheet

Posted by Evotec on Feb 11, 2021 10:35:21 AM

Download this fact sheet to learn more about Evotec's capabilities in AAV and LV application including:

Case studies
AAV production, QC and in vitro / in vivo
High quality virus production and purification

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Tags: Neuroscience, Fact Sheets

Huntington's Disease Stem Cell Research Fact Sheet

Posted by Evotec on Feb 11, 2021 10:22:01 AM

Download this fact sheet to learn more about cellular assays and stem cell research for HD including:

Case studies
High-content screening/imaging
Biochemical assays
Specifically designed HD in vitro platforms

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Tags: Neuroscience, Fact Sheets

Mutant Huntingtin Protein Assay Fact Sheet

Posted by Evotec on Feb 11, 2021 9:58:43 AM

Download this fact sheet to learn more about mutant huntingtin (mHTT) protein quantitative assay including:

Antibodies used in validation
Assay parameters
Clinical studies support services

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Tags: Neuroscience, Fact Sheets

PhosphoScout Capabilities Fact Sheet

Posted by Evotec on Feb 10, 2021 11:35:24 PM

Download this fact sheet to learn more about PhosphoScout including:

Novel technologies
Workflows
Case studies

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Tags: Neuroscience, Fact Sheets

High Content Image Analysis Fact Sheet

Posted by Evotec on Feb 10, 2021 2:28:14 PM

Download this fact sheet to learn more about high content image analysis including:

Fingerprinting of stem cell derived cultures
Automated analysis of neuronal primary cultures
Evotec's sophisticated imaging and analysis platform

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Tags: Neuroscience, Fact Sheets

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