Science Pool

After 25 years of innovative compound management support, Evotec’s sample management has expanded its operational presence by adding capacity and capabilities in Toulouse, and now offers the storage of biological material in a dedicated facility to ensure sample security and integrity.

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Enhancing throughput while reducing footprint is a recurring requirement in sample management. With the new Smartcel-2 from Flexible Lab Solutions, we have significantly boosted our capability to prepare assay-ready plates in a serial dilution format. This double-deck automation system features a Bravo from Agilent for high-volume serial dilution plate preparation and a mosquito LV from SPT Labtech for nanoliter dispensing steps. Several peripheral devices, including a peeler, sealer, centrifuge, and plate storage, enable the automation cell to operate around the clock. 

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With the growing interest in Biologics within the drug discovery field, the Evotec Sample Management teams have been asked to offer their platforms and expertise to enhance throughput and timelines by establishing robust, high-quality processes in aqueous solvents. While extensive experience with DMSO-based solvents was leveraged, the significantly different properties of the water-based solvents raised new questions regarding the handling of source and destination plates at Sample Management.
 

To address these challenges, comprehensive tests were conducted, focusing particularly on evaporation and the establishment of a device verification process. This poster presents these processes and provides an overview of the results.

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To establish a seamless connection between the CyBio Well vario liquid handling system and the Mosaic interface using the new JFM integration. This integration aims to enhance the flexibility, reliability, and user-friendliness of liquid handling operations.

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Machine Learning (ML) is becoming critical for the design and development of therapeutics. Just-Evotec Biologics has created a Humanoid Antibody Library for the discovery of biopharmaceuticals that is the first step towards leveraging artificial intelligence and ML. 

In this publication we describe how we have started the validation of the library by isolating antibodies against a target of pandemic concern, SARS-CoV-2.

We successfully identified a panel of human monoclonal antibodies that are novel, diverse, and pharmacologically active. These first-generation antibodies exhibited neutralization of SARS-CoV-2 viral infectivity across multiple strains and indicated high developability potential.

These results demonstrate the applicability of our platform for effective therapeutic antibody discovery.

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Diverse modalities are typically defined as those molecules which sit outside the rule of five characteristics for small molecules. These diverse modalities are often termed beyond the rule of five molecules, and include peptides, targeted protein degraders, oligonucleotides including ASOs, siRNAs and oligoconjugates, and proteins and monoclonal antibodies. Due to their characteristics, diverse modalities may require specialist assay design or analytical methods. 

Cyprotex has expertise in assessing the ADME-Tox for various different types of diverse modalities to ensure robust data are generated. 

Read our fact sheet to learn more about our services for assessing diverse modalities.

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Pharmacological activity is often driven by free (unbound) concentration. Blood and plasma protein binding is important for understanding the pharmacokinetics of a molecule. These measurements along with others such as tissue binding, hepatocyte binding and microsomal binding can provide an insight into distribution and elimination from the body.

Read our fact sheet to learn more about our matrix binding services.

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The J.POD technology offers cost-effective and flexible clinical and commercial supply solutions.