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BioTrinity 2023

Posted by Evotec on Mar 7, 2023 2:25:47 PM

Date: 19th - 23rd March 2023

Location: Bishopsgate, London, UK

Attending: Nigel Shipston

 

If you wish to meet with us in London, get in touch via the form below, we will be happy to arrange a meeting.

Learn more about BioTrinity 2023

Tags: Events, Evotec, Cyprotex

Potent targeted activator of cell kill molecules eliminate cells expressing HIV-1

Posted by Evotec on Mar 7, 2023 12:05:56 PM

Originally presented in Science Translational Medicine, this article co-written with Merck & Co. presents a set of bifunctional HIV therapies, dubbed targeted activator of cell kill (TACK) molecules, that were optimized for simultaneous antiviral activity and selective elimination of infected CD4+ T cells from HIV-1 patients.

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Tags: Articles & Whitepapers, Structural Biology & Protein Science, Immunology & Inflammation

Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2

Posted by Evotec on Mar 7, 2023 11:55:59 AM

Variants of isocitrate dehydrogenase IDH 1 and 2 are known to alter the metabolism in cancer cells. Through a combined approach of X-ray crystallography and 1H NMR in collaboration with Christopher Schofield from University of Oxford, we reveal that 2OG derivatives can serve as substrates of the investigated IDH1/2 variants, but not of WT IDH1/2, and have the potential to act as 2OG-competitive inhibitors.

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Tags: Oncology, Articles & Whitepapers, Structural Biology & Protein Science

7th RSC/SCI Symposium on Ion Channels as Therapeutic Targets

Posted by Evotec on Mar 1, 2023 1:51:15 PM

Date: 27 - 28 March 2023

Location: Cambridge, UK

Attending: Dr Anna Carbone and Dr Luca Raveglia 

Join us in-person in Cambridge for the 7th RSC/SCI Symposium on Ion Channels as Therapeutic Targets where Evotec will be presenting it's science.

 

Dr Anna Carbone from EPhys team in Hamburg will be speaking about EVOchannel safety platform.

Dr Luca Raveglia from Medicinal Chemistry in Verona will be presenting on TRPM5 project.

 

Learn more about the Symposium on Ion Channels as Therapeutic Targets  

Tags: Events, Evotec, Just Evotec Biologics

4th Summit on Stem Cell Derived Beta Cells

Posted by Evotec on Mar 1, 2023 1:43:55 PM

Date: 24 - 25 April 2023

Location: Cambridge, MA

Attending: Matthias Austen and Christine Guenther 

Join us in-person in Cambridge for the 4th IPITA/HSCI/JDRF Summit on Stem Cell Derived Beta Cells where Evotec will be sponsoring and presenting it's science in collaboration with Sernova.

Presentation | April 24 from 2:45 - 4:25om ET
Manufacturing of optimized human islet-like clusters (ILCs) from iPSCs and functional testing of an ILC + Cell Pouch™ combination in vivo

Evotec has developed a scalable and comprehensive process for GMP manufacturing of ILCs from a human GMP-grade induced pluripotent stem cell (iPSC) line for cell therapy in human insulin-dependent diabetes. In 2022, Evotec entered into a collaboration with Sernova Corp., which has developed the proprietary Cell Pouch System™. Following implantation, the Cell Pouch develops a vascularized environment to support engraftment and long-term function of therapeutic cells. 

Authors: Audrey Holtzinger, Simone Strauch, Thomas Reinbothe, Claudia Wrzos, Andreas Scheel, Cord Dohrmann, Arash Memarnejadian, Pardis Pakshir, Philip M. Toleikis, Matthias Austen

Sernova will disclose additional information about the presentation at the time of the conference.

Learn more about the Summit on Stem Cell Derived Beta Cells

Tags: Events, Evotec, Just Evotec Biologics

Quality Assurance-Based Key Performance Indicators

Posted by Evotec on Mar 1, 2023 1:33:19 PM

In November 2022, our Quality Assurance expert Michelle Manton presented the topic of Quality Assurance-Based Key Performance Indicators (KPIs) at the RQA International QA Conference in Brighton, alongside other members of the GLP Committee.

This article captures the discussions and feedback received during that workshop with the intention of promoting reflection on how experts in the quality profession use KPIs, what they aim to achieve and how they can use KPIs or similar metrics to drive continuous improvement – the heart of any robust ‘future-proofed’ Quality Management System (QMS).

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Tags: Articles & Whitepapers, Blog

33rd European Congress of Clinical Microbiology & Infectious Diseases 2023 (ECCMID)

Posted by Evotec on Mar 1, 2023 1:12:15 PM

Date: 15th - 18th April 2023

Location: Copenhagen, Denmark

Attending: Sneha Kumar, Senior Director Business Development; Kirsty Holden, Head of Lead Generation; Francesca Bernardini, VP In Vitro Biology, Infectious Diseases; David Corbett, Group Leader Anti-Infectives; AM Spiroski, Group Leader Anti-Infectives; Hugh Watson, Principle Manager of Clinical Development; Livia Ferrari, Senior Manager Translational Biology.

ECCMID is Europe's largest Clinical Microbiology & Infectious Diseases event which unites experts from numerous fields to present their latest findings, guidelines, and research to an international audience. This year, the congress will feature a hybrid format to facilitate onsite and online participation for attendees, allowing remote and face-to-face opportunities. 

Connect with our scientific specialists at booth #ES25-1A and don't forget to include our poster and oral presentation in your ECCMID itinerary!

Our scientific program

Poster Presentations  

Development of a non-surgical Staphylococcus aureus mouse bone infection model

Presenting Author: AM Spiroski, Group Leader Anti-Infectives
Date: Saturday 15th April 
Time: 12:00pm CET
Abstract / Poster #: P1041

Efficacy of aztreonam-avibactam against a metallo-lactamase producing strain of Escherichia coli in the hollow fiber infection model

Presenting Author: David Corbett, Group Leader Anti-Infectives
Date: Monday 17th April 
Time: 12:00pm CET
Abstract / Poster #: P2179

In vivo efficacy of RG6006 against in vitro-generated resistant mutants of Acinetobacter baumannii

Presenting Author: Livia Ferrari, Senior Manager, Translational Biology
Date: Monday 17th April 
Time: 12:00pm CET
Abstract / Poster #: P2103

Efficacy of RG6006 in murine models of infections, including sepsis, thigh and lung induced by Acinetobacter 

Presenting Author: Livia Ferrari, Senior Manager, Translational Biology
Date: Monday 17th April 
Time: 12:00pm CET
Abstract / Poster #: P2102

Oral Presentation  

Chikungunya viral kinetics and the challenge for an antiviral treatment

Presented By: Hugh Watson Principle Manager Clinical Development
Date: Saturday 16th April
Time: 8:30am CET
Room: Hall B

 

 

Let's Break for Science | Booth #ES-25 1A
Drop by our booth at 10:30am and 3:30pm for a 10-minute bite-sized, interactive & educational session
 

Chikungunya viral kinetics

Date: Saturday 15th April 
Time: 3:45pm CET

A guided walk through in vitro pharmacology for AMR and Tuberculosis

Date: Sunday 16th April
Time: 10:30am CET

Integrated in vivo pharmacology: Designing the correct model for your projects

Date: Sunday 16th April
Time: 3:45pm CET

The Hollow Fibre Infection Model: Understanding your PK/PD relationship

Date: Monday 17th April
Time: 10:30am CET

Integrated in vivo pharmacology: Designing the correct model for your projects

Date: Monday 17th April
Time: 3:45pm CET

A guided walk through in vitro pharmacology for AMR and Tuberculosis

Date: Tuesday 18th April
Time: 10:30am CET

   

If you wish to meet with us in Copenhagen get in touch via the form below and we will be happy to arrange a meeting

Learn more about the 33rd European Congress of Clinical Microbiology & Infectious Diseases

Tags: Events, Evotec

Oxford Global Biologics Meeting 2023

Posted by Evotec on Feb 28, 2023 11:38:36 AM

Date: 19th - 23rd March 2023

Location: London, UK

Attending: Nigel Shipston, Senior Director Business Development

Join us in-person in London for Oxford Global’s Biologics 2023 meeting. 

Learn more about the 62nd SOT Annual Meeting and ToxExpo

Tags: Events, Evotec, Just Evotec Biologics

Bio Korea

Posted by Evotec on Feb 27, 2023 2:46:02 PM

Date: 10 - 12 May 2023

Location: COEX, SEOUL

Attending: Tim Potter and Nicholas Johnson

Booth Number: 58 

logo

Learn more about Bio Korea

Tags: Events, Evotec, Cyprotex

34th Medicinal Chemistry in Eastern England

Posted by Evotec on Feb 27, 2023 2:42:44 PM

Date: 27 April 2023 

Location: Fielder Centre, Hatfield

Attending: Oksana Nikolayenko 

Learn more about 34th Medicinal Chemistry in Eastern England

Tags: Events, Cyprotex