Originally presented in Science Translational Medicine, this article co-written with Merck & Co. presents a set of bifunctional HIV therapies, dubbed targeted activator of cell kill (TACK) molecules, that were optimized for simultaneous antiviral activity and selective elimination of infected CD4+ T cells from HIV-1 patients.
Tags: Articles & Whitepapers, Structural Biology & Protein Science, Immunology & Inflammation
Variants of isocitrate dehydrogenase IDH 1 and 2 are known to alter the metabolism in cancer cells. Through a combined approach of X-ray crystallography and 1H NMR in collaboration with Christopher Schofield from University of Oxford, we reveal that 2OG derivatives can serve as substrates of the investigated IDH1/2 variants, but not of WT IDH1/2, and have the potential to act as 2OG-competitive inhibitors.
Tags: Oncology, Articles & Whitepapers, Structural Biology & Protein Science
Date: 27 - 28 March 2023
Location: Cambridge, UK
Attending: Dr Anna Carbone and Dr Luca Raveglia
Join us in-person in Cambridge for the 7th RSC/SCI Symposium on Ion Channels as Therapeutic Targets where Evotec will be presenting it's science.
Dr Anna Carbone from EPhys team in Hamburg will be speaking about EVOchannel safety platform.
Dr Luca Raveglia from Medicinal Chemistry in Verona will be presenting on TRPM5 project.
Learn more about the Symposium on Ion Channels as Therapeutic Targets
Tags: Events, Evotec, Just Evotec Biologics
Date: 24 - 25 April 2023
Location: Cambridge, MA
Attending: Matthias Austen and Christine Guenther
Join us in-person in Cambridge for the 4th IPITA/HSCI/JDRF Summit on Stem Cell Derived Beta Cells where Evotec will be sponsoring and presenting it's science in collaboration with Sernova.
Presentation | April 24 from 2:45 - 4:25om ET
Manufacturing of optimized human islet-like clusters (ILCs) from iPSCs and functional testing of an ILC + Cell Pouch™ combination in vivo
Evotec has developed a scalable and comprehensive process for GMP manufacturing of ILCs from a human GMP-grade induced pluripotent stem cell (iPSC) line for cell therapy in human insulin-dependent diabetes. In 2022, Evotec entered into a collaboration with Sernova Corp., which has developed the proprietary Cell Pouch System™. Following implantation, the Cell Pouch develops a vascularized environment to support engraftment and long-term function of therapeutic cells.
Authors: Audrey Holtzinger, Simone Strauch, Thomas Reinbothe, Claudia Wrzos, Andreas Scheel, Cord Dohrmann, Arash Memarnejadian, Pardis Pakshir, Philip M. Toleikis, Matthias Austen
Sernova will disclose additional information about the presentation at the time of the conference.
Tags: Events, Evotec, Just Evotec Biologics
In November 2022, our Quality Assurance expert Michelle Manton presented the topic of Quality Assurance-Based Key Performance Indicators (KPIs) at the RQA International QA Conference in Brighton, alongside other members of the GLP Committee.
This article captures the discussions and feedback received during that workshop with the intention of promoting reflection on how experts in the quality profession use KPIs, what they aim to achieve and how they can use KPIs or similar metrics to drive continuous improvement – the heart of any robust ‘future-proofed’ Quality Management System (QMS).
Tags: Articles & Whitepapers, Blog
Date: 15th - 18th April 2023
Location: Copenhagen, Denmark
Attending: Sneha Kumar, Senior Director Business Development; Kirsty Holden, Head of Lead Generation; Francesca Bernardini, VP In Vitro Biology, Infectious Diseases; David Corbett, Group Leader Anti-Infectives; AM Spiroski, Group Leader Anti-Infectives; Hugh Watson, Principle Manager of Clinical Development; Livia Ferrari, Senior Manager Translational Biology.
ECCMID is Europe's largest Clinical Microbiology & Infectious Diseases event which unites experts from numerous fields to present their latest findings, guidelines, and research to an international audience. This year, the congress will feature a hybrid format to facilitate onsite and online participation for attendees, allowing remote and face-to-face opportunities.
Connect with our scientific specialists at booth #ES25-1A and don't forget to include our poster and oral presentation in your ECCMID itinerary!
Our scientific program
If you wish to meet with us in Copenhagen get in touch via the form below and we will be happy to arrange a meeting
Learn more about the 33rd European Congress of Clinical Microbiology & Infectious Diseases
Date: 19th - 23rd March 2023
Location: London, UK
Attending: Nigel Shipston, Senior Director Business Development
Join us in-person in London for Oxford Global’s Biologics 2023 meeting.
Tags: Events, Evotec, Just Evotec Biologics
Date: 10 - 12 May 2023
Location: COEX, SEOUL
Attending: Tim Potter and Nicholas Johnson
Booth Number: 58
Date: 27 April 2023
Location: Fielder Centre, Hatfield
Attending: Oksana Nikolayenko
Learn more about 34th Medicinal Chemistry in Eastern England
Date: 28 - 29 March 2023
Location: Wiesbaden, Germany
Attending: Daniel Gliesche
