Bioinformatics supporting Infectious Disease: Creating knowledge for efficient discovery and development of better medicines.
Pathogen functional genomics analyses for unbiased, multidimensional small molecule effect characterisation (RNA-, DNA-seq analyses to characterise pathogen genome and transcriptome)
Genome assembly and annotation with a focus on resistance and virulence (Illumina, ONT, hybrid)
- Short- (SNP, short indels) and long-range (insertion, deletion, inversion, translocation, duplication) variant analysis associated with resistance (Illumina, ONT)
- Bacterial genome wide association study (GWAS)
- Transcriptome analysis (RNAseq) and functional interpretation
- Bacterial population sequencing and variant characterisation (PoolSeq)
- Molecular phylogeny
- Network analysis (enrichment analysis, pathway mapping)