The Seahorse extracellular flux analyzer uses the mitochondrial stress test to determine cellular metabolism and mitochondrial function. It detects, in real time, the effects of a compound on the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) of the cell and determines potential mitochondrial toxicity.
Read our fact sheet to learn more about our mitochondrial toxicity service using the Seahorse extracellular flux analyzer.
Tags: Fact Sheets, Toxicology & Safety, Cyprotex
At Evotec, our expert immunologists drive your immuno-oncology projects from target identification to clinical trials. We offer comprehensive support for integrated projects and specialized expertise at critical stages. Our services include bespoke in vitro immunological assays, genetic engineering of primary immune cells, and advanced preclinical models. By integrating cutting-edge technologies and leveraging our extensive clinician network, we ensure the successful translation of innovative cancer immunotherapies from the lab to the clinic. Partner with Evotec to advance your cancer immunotherapy research and achieve breakthrough results.
Tags: Oncology, immuno-oncology, Fact Sheets, In vitro Biology, Proteomics, Metabolomics & Biomarkers, Cell Therapy
Quality Hits At Lightning Speed - Accelerated Hit Finding Through Innovative Screening Approaches.
Read our fact sheet to learn about Evotec’s capabilities, infrastructure and expertise for hit identification and HTS projects.
Tags: Fact Sheets, Hit & Target ID/Validation, In vitro Biology
Just - Evotec Biologics is at the forefront of biomanufacturing innovation with its JP3 platform. By integrating intensified perfusion cell culture and fully connected downstream processing, we achieve remarkable productivity and cost efficiency. Our approach not only boosts output but also ensures consistent, high-quality biotherapeutics.
Leveraging AI/ML technologies and advanced process intensification, Just - Evotec Biologics is setting new industry standards. Our continuous manufacturing process significantly reduces costs and expands global access to essential biotherapeutics.
Tags: Oncology, Fact Sheets, Formulation & CMC, Biologics, Immunology & Inflammation, Rare Diseases
Tags: Fact Sheets, Sample Management
Diverse modalities are typically defined as those molecules which sit outside the rule of five characteristics for small molecules. These diverse modalities are often termed beyond the rule of five molecules, and include peptides, targeted protein degraders, oligonucleotides including ASOs, siRNAs and oligoconjugates, and proteins and monoclonal antibodies. Due to their characteristics, diverse modalities may require specialist assay design or analytical methods.
Cyprotex has expertise in assessing the ADME-Tox for various different types of diverse modalities to ensure robust data are generated.
Read our fact sheet to learn more about our services for assessing diverse modalities.
Tags: Fact Sheets, ADME/DMPK, Toxicology & Safety, Cyprotex
Pharmacological activity is often driven by free (unbound) concentration. Blood and plasma protein binding is important for understanding the pharmacokinetics of a molecule. These measurements along with others such as tissue binding, hepatocyte binding and microsomal binding can provide an insight into distribution and elimination from the body.
Read our fact sheet to learn more about our matrix binding services.
Tags: Fact Sheets, ADME/DMPK, Cyprotex
Physicochemical properties provide an insight into the structure of a molecule and its physical behavior within a system, and they can influence its dissolution, absorption, distribution, metabolism, elimination, protein affinity and toxicity. Early assessment of a molecule's physicochemical properties supports rational compound design within drug discovery.
Read our fact sheet to learn more about our physicochemical profiling services.
Tags: Fact Sheets, ADME/DMPK, Cyprotex, Modelling and Simulation
Membrane permeability plays an important role in oral absorption. Cyprotex offers a range of in vitro permeability assays to understand passive permeability or transporter-mediated effects.
Read our fact sheet to learn more about our in vitro permeability services.
Tags: Fact Sheets, ADME/DMPK, Cyprotex
Understand if your investigational drug has the potential to be a perpetrator (precipitant) of transporter-mediated drug-drug interactions by evaluating if it is an inhibitor of drug transporters.
Read our fact sheet to learn more about our transporter inhibition service.
Tags: Fact Sheets, ADME/DMPK, IND Enabling Studies/Preclinical Development, Cyprotex