Mitobiogenesis (or mitochondrial biogenesis) is defined as the growth and division of pre-existing mitochondria. Drug-induced perturbations in this process can result in mitochondrial dysfunction or toxicity. 

In this presentation, we focus on:

• mechanisms involved in mitochondrial toxicity including drug-induced mitobiogenesis
• the development of a high throughput high content imaging assay for detecting drug-induced effects on mitobiogenesis
• validation of the assay using known drugs which inhibit mitochondrial DNA and protein synthesis (e.g., antibiotics, anti-viral and anticancer drugs) as well as some non-mitochondrial toxicants.

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