Science Pool

Presentation slide deck for the webinar Deciphering the Clinincal DDI Between Atazanavir and Rosuvastatin.

Interesed in Evotec's Translational Molecular Patient Database? 

In this presentation, first presented at our luncheon during German Biotechnology Days, focuses on:

• The database's over 200,000 samples and data from over 15,000 patients
• Data-driven approaches for better diagnoses
• Categorization by disease mechanisms

View the presentation to learn more!

LEARN MORE

Learn more about Multi-Omic Analysis of Induced Biotherapeutic Protein Production in CHO Cells Reveals Substantial Shifts in Energy Allocation in this presentation from PEGS Boston - Optimizing Protein Expression from May 2021. 

In this presentation, we focus on:

• Experimental design
• Data processing and analysis in transcriptomics
• Multivariate 'omic analysis
• CHO clone screenings

Learn more about biomanufacturing at Just-Evotec Biologics by downloading this presentation first presented at IFPAC in March 2021.

In this presentation, we touch on:

• Historic manufacturing practices
• Macro trends impacting affordability
• Speed and flexible capacity solutions
• New plan design principles

The skin is the largest organ in the human body. It contains enzymes capable of drug metabolism.

In this presentation, we focus on:

• the physiology of the skin and an overview of skin enzymology
• the role of skin metabolism in absorption, efficacy, homeostasis, drug delivery and toxicity
• adverse reactions in the skin including the mechanism behind skin sensitisation
• in vitro methods for investigating skin metabolism

View the presentation to learn more!

LEARN MORE

LC-MS provides the analytical endpoint for most discovery ADME assays. There is a constant drive to reduce LC-MS run times whilst maintaining quality. 

In this presentation, we focus on:

• a comparison of triple quadrupole MS/MS vs TripleTOF MS
• validation data for performance of the TripleTOF MS 
• use of the TripleTOF in high throughput ADME screening including intrinsic clearance assays and soft spot analysis.

View the presentation to learn more!

LEARN MORE

Due to an aging population, polypharmacy is increasing. Drug-drug interactions account for 5% of UK hospital admissions, and are a particular concern for common co-meds such as statins.

In this presentation, we focus on:

• a background to drug-drug interactions (DDI)
• the use of the mechanistic static models in the prediction of transporter-mediated DDI
• a comparison of the different published models and their performance 

View the presentation to learn more!

LEARN MORE

Pilocarpine is a muscarinic cholinergic agonist which is used as an epilepsy model in rats. 

In this presentation, we evaluate:

• the seizurogenic response of pilocarpine in vitro in different neuronal models including rat cortical neurons, rat hippocampal neurons and a human iPSC-derived co-culture model
• the importance of maturation of the cells (DIV)
• the use of MEA for the sensitive detection of firing, bursting and synchrony of the cells

View the presentation to learn more!

LEARN MORE

Human-derived 3D cell-based models are more representative of in vivo cellular physiology and have improved longevity in vitro.  

In this presentation, we focus on:

• causes of drug failure in drug development
• the advances in high content screening
• developments in 3D cell-based models including organ-specific cellular models
• the prediction of tissue specific toxicities such as hepatotoxicity (DILI), cardiotoxicity, nephrotoxicity and neurotoxicity

View the presentation to learn more!

LEARN MORE