---
title: Understanding the Mechanism behind Pilocarpine Neurotoxicity
description: View our presentation on evaluation of pilocarpine by MEA in multiple neuronal cell types. Contact Evotec to learn more!
image: https://news.cyprotex.com/hubfs/Sciencepool/Sciencepool%20images/Shutterstock%20images/shutterstock_710281876-neuron-blue-03-science-pool.jpg
---

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# Science Pool

# Understanding the Mechanism behind Pilocarpine Neurotoxicity

Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Feb 12, 2021 5:18:48 PM

Pilocarpine is a muscarinic cholinergic agonist which is used as an epilepsy model in rats. 

In this presentation, we evaluate:

- the seizurogenic response of pilocarpine *in vitro* in different neuronal models including rat cortical neurons, rat hippocampal neurons and a human iPSC-derived co-culture model
- the importance of maturation of the cells (DIV)
- the use of MEA for the sensitive detection of firing, bursting and synchrony of the cells

View the presentation to learn more!

[LEARN MORE](https://news.cyprotex.com/hubfs/Sciencepool/Presentations/Cyprotex%20presentations/pilocarpine-mea-evaluation-multiple-neuronal-cell-types-sps2018.pdf)

 

 

 

 Tags: [Toxicology](https://news.cyprotex.com/sciencepool/tag/toxicology), [Presentations](https://news.cyprotex.com/sciencepool/tag/presentations)