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title: Use of Quantitative LC-MS/MS Methods to Compare Conventional Blood Collection and Microsampling in Non-human Primate
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Read our poster. Use of quantitative LC-MS/MS methods to compare conventional blood collection and microsampling in non-human primate
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---

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# Science Pool

# Use of Quantitative LC-MS/MS Methods to Compare Conventional Blood Collection and Microsampling in Non-human Primate

Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Jun 21, 2022 2:52:09 PM

Toxicokinetic evaluation is a regulatory and scientific requirement in the drug development process. To obtain plasma, blood is generally withdrawn by a conventional venous collection method. Microsampling is a less invasive sampling technique, which allows to reduce the stress correlated to the conventional blood sampling and to decrease the number of rodents for a preclinical study. The implementation of microsampling in particular, in non-human primate can reduce the stress and promote a positive interaction with technical staff which improves the overall well-being of the animal (refinement).

In this poster we summarise the work done to evaluate the possible influence of the blood sampling method on drug plasma concentrations, using LC-MS/MS methods in non-human primate for four drugs selected based on acid-base and volume of distribution properties.

The poster was presented by our expert Rossella Cardin at the 24th International Reid Bioanalytical Forum held in Cambridge, UK, on June 13-16, 2022.

 

[DOWNLOAD](https://news.cyprotex.com/hubfs/Sciencepool/Posters/Evotec%20posters/quantitative-LC-MS-MS-blood-collection-microsampling.pdf)

 Tags: [Posters](https://news.cyprotex.com/sciencepool/tag/posters), [ADME/DMPK](https://news.cyprotex.com/sciencepool/tag/adme-dmpk), [IND Enabling Studies/Preclinical Development](https://news.cyprotex.com/sciencepool/tag/ind-enabling-studies-preclinical-development), [Toxicology & Safety](https://news.cyprotex.com/sciencepool/tag/toxicology-safety)