Science Pool

Read case studies and user perspectives on how the PanHunter platform is transforming the value of multi-omics data.

As the CNS is a complex organ system, neurotoxicity can be difficult to assess and detect during preclinical development in animal models.

In this poster, we focus on:

• the use of cell-based models in conjunction with MEA to identify neurogenic and seizurogenic compounds
• a comparison between rat cortical neurons and a co-culture of human iPSC-derived glutamatergic neurons with iPSC-derived astrocytes in their response to known neurotoxic and seizurogenic compounds  
• a recommended in vitro screening approach for early detection of neurotoxicity

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During analysis of samples from HT-ADME screening, non-specific binding can cause challenges due to accumulation within the analytical system. This can result in poor peak shape, low sensitivity, increasing back pressure/pressure spikes, carryover or system clogging.  

In this poster, we focus on:

• the evaluation of the Waters^TM Acquity Premier UPLC in conjunction with the Acquity Premier HSS T3 column technology which contain an inert coating specifically formulated to eliminate analyte/surface interactions
• a comparison with standard UPLC technology
• details on the benefits of using the Waters Acquity^TM system in terms of chromatographic performance and sensitivity

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Cardiotoxicity in response to pharmaceutical drugs, chemicals and environmental toxicants can develop as a result of changes in structural integrity of cardiac tissue or functional changes in cardiac electrophysiology. The development of new approach methodologies (NAMs) is important in predicting these cardiotoxic liabilities.

In this poster, we focus on:

• the use of human iPSC-derived cardiomyocytes in combination with a panel of in vitro toxicology assays including:
  • calcium transient monitoring
  • high content imaging of morphological changes
  • cellular ATP assessment
  • high throughput transcriptomics using RNA-seq
• the results from profiling 42 compounds in the assessment of structural and functional endpoints along with predictive outcome (sensitivity, specificity and accuracy)
• mechanistic information including the detection of biological pathways associated with the cardiotoxic effects

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The cytochrome P450 enzyme, CYP46A1, is predominantly expressed in the brain and plays a major role in cholesterol metabolism by converting cholesterol to 24-hydroxy cholesterol.

In this poster, we focus on:

• the development and validation of an in vitro high throughput screening platform for characterisation of inhibitors and activators of CYP46A1
• a comparison of testosterone with cholesterol as a potential replacement probe substrate for studying CYP46A1 metabolism
• data generated from a screening cascade of 2321 FDA approved drugs

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E.SOLVE is Evotec's solution to accelerate your journey to the clinic supporting your formulation strategy as early as possible from discovery to market approval.

Download this fact sheet to learn more about how E.SOLVE's full range of approaches improve solubilization and bioavailability to ensure that your API can progress through the drug discovery development pipeline faster.

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Download this fact sheet to learn more about formulating your way to successful toxicology studies including:

• Early formulation
• Material science - solid development
• DMPK
• In vitro, in vivo, and in silico models

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