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Development of Potential PET Ligand for Imaging Mutant Huntingtin Aggregates

Posted by Evotec on Sep 13, 2021 8:06:10 PM

Mutant huntingtin (mHTT) forms protein aggregates characteristic of Huntington's Disease pathology.

In this publication, we focus on:

a background to Huntington's Disease including the mutant huntingtin gene (mHTT)
a discussion of the benefits of sensitive biomarkers to monitor disease progression
the discovery of an mHTT aggregate-specific PET ligand suitable for live brain imaging

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Tags: Neuroscience, Articles & Whitepapers, In vivo Pharmacology

Pharmacological Characterization of Mutant Huntingtin Aggregate-Directed PET Imaging Tracer Candidates

Posted by Evotec on Sep 13, 2021 8:03:47 PM

Huntington's Disease is caused a mutation in the huntingtin (mHTT) gene which codes for the huntingtin (HTT) protein.

In this publication, we focus on:

a background to link between Huntington's Disease and the mutant huntingtin gene (mHTT)
the development of PET tracers for imaging mHTT aggregates
characterisation of these PET tracers including pharmacological investigation of their binding affinities and selectivity

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Tags: Neuroscience, Articles & Whitepapers, In vitro Biology, In vivo Pharmacology

ELRIG Pharmaceutical Flow Cytometry & Imaging 2021

Posted by Evotec on Sep 10, 2021 9:39:13 AM

Date: 30th November - 1st December 2021

Location: Circle Square, Oxford Road, Manchester

Attendee: Oksana Nikolayenko

Learn more about ELRIG Pharmaceutical Flow Cytometry & Imaging 2021

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Tags: Events, Cyprotex

World Antiviral Congress 2021

Posted by Evotec on Sep 10, 2021 9:28:10 AM

Date: 30th November - 02nd December 2021

Location: Loews Coronado Bay Resort, San Diego

Attendee: David Cerny

Learn more about World Antiviral Congress 2021

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Tags: Events, Cyprotex

Pharmacokinetic Prediction Fact Sheet

Posted by Evotec on Sep 9, 2021 5:52:45 PM

Learn more about human pharmacokinetic prediction including:

background information on the predictive model
in vitro ADME data and structural data requirements for PK prediction
data delivered for the PK prediction
validation data for the predictive model

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Tags: Fact Sheets, ADME/DMPK, Modelling and Simulation

New York Society of Cosmetics Chemists Suppliers' Day 2021

Posted by Evotec on Sep 7, 2021 2:39:04 PM

Date: 10^th – 12^th November 2021

Location: Jacob K. Javits Convention Centre, New York City

Booth Number: Level 1, Booth 941

Attendee: Ralf Geiben Lynn

Learn more about New York Society of Cosmetics Chemists Suppliers' Day 2021

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Tags: Events, Cyprotex

Brain Tissue Binding Fact Sheet

Posted by Evotec on Sep 1, 2021 3:17:35 PM

Learn more about the brain tissue binding assay including:

Background information
Assay details and protocol summary
Data generated in the brain tissue binding assay

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Tags: Fact Sheets, ADME/DMPK

Cytochrome P450 Time Dependent Inhibition (IC50 Shift) Fact Sheet

Posted by Evotec on Sep 1, 2021 3:13:19 PM

Learn more about the cytochrome P450 time dependent inhibition (CYP TDI) IC₅₀ shift assay including:

Background information
Assay details and protocol summary
Data generated in the CYP TDI IC₅₀ shift assay

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Tags: Fact Sheets, ADME/DMPK

Chronic Exposure Nephrotoxicity Assay Fact Sheet

Posted by Evotec on Sep 1, 2021 3:10:26 PM

Learn more about our chronic exposure nephrotoxicity assay including:

Background information
Assay details and protocol summary
Data generated in the chronic exposure nephrotoxicity assay

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Tags: Fact Sheets, Toxicology & Safety

Blood Binding Fact Sheet

Posted by Evotec on Sep 1, 2021 3:09:22 PM

Learn more about the whole blood binding assay including:

Background information
Assay details and protocol summary
Data generated in the whole blood binding assay

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Tags: Fact Sheets, ADME/DMPK

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