| Articles & Whitepapers (10)

The field of high-throughput ADME (HT-ADME) places a greater demand on the analytical systems supplying end point quantification.

In this review, we focus on:

recent technological advances in LC–MS/MS which dramatically reduce sample analysis time
evaluating the impact of reduced sample analysis time on analytical data quality
the use of appropriate LC-MS/MS systems
software tools to aid bioanalytical quality

Read our publication to learn more!

LEARN MORE

Drug-induced mitochondrial dysfunction has been associated with organ toxicity and drug withdrawal. Highly specific and sensitive in vitro assays have been developed to predict mitochondrial dysfunction.

In this publication, we focus on:

a background to mitochondrial toxicity
a comparison of the Glu/Gal mitochondrial assay with the Seahorse assay for the prediction of mitochondrial toxicity
how the Seahorse assay provides a mechanistic understanding of mitochondrial toxicity

Read our publication to learn more!

LEARN MORE

Drug-induced liver injury (DILI) is a leading cause of drug failure due to poor translation between traditional preclinical animal models and human clinical outcome. More sophisticated human in vitro cell-based models with multiparametric endpoints are now being developed to improve DILI prediction.

In this review article, we focus on:

the evolution of the strategies adopted to improve human hepatotoxicity prediction in drug discovery
how companies are addressing translational challenges using human relevant cell-based models
a further insight into the key role of human exposure and hepatic drug uptake transporters (e.g., OATPs, OAT2)

Read our publication to learn more!

LEARN MORE

Science Pool

Endometriosis - the Bayer-Evotec Alliance

Bridging the Drug Discovery Gap

Partnerships in Drug Discovery and Development Build Success

The Next Generation of Antibiotics

Can Biomarkers help us to Develop Personalised Medicine Faster?

How to Boost your Structure-Based Drug Design

How Proteomics Boosts the Discovery of Novel Drugs and Biomarkers

Ensuring Bioanalytical Quality in a Highly Automated HT-ADME Laboratory

Improving the Prediction of Mitochondrial Toxicity

Strategies to Minimise the Risk of DILI