--- title: | Immunology & Inflammation description: Immunology & Inflammation | --- [![Cyprotex | The Leading ADME-Tox Specialist](https://news.cyprotex.com/hs-fs/hubfs/cyprotex%20logo.png?width=224&height=62&name=cyprotex%20logo.png "Cyprotex | The Leading ADME-Tox Specialist")](https://www.cyprotex.com/) # Science Pool ## [Integrative Analysis of Human Macrophage Inflammatory Response Related to Mycobacterium Tuberculosis Virulence](https://news.cyprotex.com/sciencepool/integrative-analysis-of-human-macrophage-inflammatory-response-related-to-mycobacterium-tuberculosis-virulence) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Jan 11, 2022 4:36:26 PM *Mycobacterium tuberculosis* (Mtb), the etiological agent of tuberculosis, kills 1.5 to 1.7 million people every year. Macrophages are Mtb’s main host cells and their inflammatory response is an essential component of the host defense against Mtb. However, Mtb is able to circumvent the macrophages’ defenses by triggering an inappropriate inflammatory response. Understanding macrophage interactions with Mtb is crucial to develop strategies to control tuberculosis. The present study aims to determine the inflammatory response transcriptome and miRNome of human macrophages infected with the virulent H37Rv Mtb strain, to identify macrophage genetic networks specifically modulated by Mtb virulence. [LEARN MORE](https://www.frontiersin.org/articles/10.3389/fimmu.2021.668060/full) 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/integrative-analysis-of-human-macrophage-inflammatory-response-related-to-mycobacterium-tuberculosis-virulence#comments-listing) Tags: [Medicinal Chemistry](https://news.cyprotex.com/sciencepool/tag/medicinal-chemistry), [Articles & Whitepapers](https://news.cyprotex.com/sciencepool/tag/articles-whitepapers), [In vitro Biology](https://news.cyprotex.com/sciencepool/tag/in-vitro-biology), [Anti-Infectives](https://news.cyprotex.com/sciencepool/tag/anti-infectives), [Immunology & Inflammation](https://news.cyprotex.com/sciencepool/tag/immunology-inflammation) ## [Prostaglandin E Synthase-1 Inhibitors for Endometriosis Treatment](https://news.cyprotex.com/sciencepool/prostaglandin-e-synthase-1-inhibitors-for-endometriosis-treatment) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Mar 11, 2021 8:23:50 PM 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/prostaglandin-e-synthase-1-inhibitors-for-endometriosis-treatment#comments-listing) Tags: [Medicinal Chemistry](https://news.cyprotex.com/sciencepool/tag/medicinal-chemistry), [Evotec](https://news.cyprotex.com/sciencepool/tag/evotec), [Women's health](https://news.cyprotex.com/sciencepool/tag/womens-health), [Immunology & Inflammation](https://news.cyprotex.com/sciencepool/tag/immunology-inflammation) ## 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[Inhibition of NF-kB Inducing Kinase in IFNα-accelerated Lupus Nephritis](https://news.cyprotex.com/sciencepool/selective-inhibition-of-nf-kb-inducing-kinase-in-ifnα-accelerated-lupus-nephritis) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Mar 5, 2021 5:36:55 PM 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/selective-inhibition-of-nf-kb-inducing-kinase-in-ifnα-accelerated-lupus-nephritis#comments-listing) Tags: [Kidney diseases](https://news.cyprotex.com/sciencepool/tag/kidney-diseases), [Articles & Whitepapers](https://news.cyprotex.com/sciencepool/tag/articles-whitepapers), [In vivo Pharmacology](https://news.cyprotex.com/sciencepool/tag/in-vivo-pharmacology), [Immunology & Inflammation](https://news.cyprotex.com/sciencepool/tag/immunology-inflammation), [Metabolic Disease & Complications](https://news.cyprotex.com/sciencepool/tag/metabolic-disease-complications) ## [Design, Synthesis & SAR of IL2 Inducible T Cell Kinase Inhibitors](https://news.cyprotex.com/sciencepool/design-synthesis-sar-of-il2-inducible-t-cell-kinase-inhibitors) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Mar 5, 2021 11:54:08 AM 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/design-synthesis-sar-of-il2-inducible-t-cell-kinase-inhibitors#comments-listing) Tags: [Medicinal Chemistry](https://news.cyprotex.com/sciencepool/tag/medicinal-chemistry), [Respiratory](https://news.cyprotex.com/sciencepool/tag/respiratory), [Articles & Whitepapers](https://news.cyprotex.com/sciencepool/tag/articles-whitepapers), [Immunology & Inflammation](https://news.cyprotex.com/sciencepool/tag/immunology-inflammation) ## [NF-κB Inducing Kinase: A Therapeutic Target for Systemic Lupus Erythematosus](https://news.cyprotex.com/sciencepool/nf-κb-inducing-kinase-a-therapeutic-target-for-systemic-lupus-erythematosus) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Mar 4, 2021 10:32:47 PM 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/nf-κb-inducing-kinase-a-therapeutic-target-for-systemic-lupus-erythematosus#comments-listing) Tags: [Articles & Whitepapers](https://news.cyprotex.com/sciencepool/tag/articles-whitepapers), [Hit & Target ID/Validation](https://news.cyprotex.com/sciencepool/tag/hit-target-id-validation), [Immunology & Inflammation](https://news.cyprotex.com/sciencepool/tag/immunology-inflammation) ## [Therapeutic Potential of NADPH Oxidase 1/4 Inhibitors](https://news.cyprotex.com/sciencepool/therapeutic-potential-of-nadph-oxidase-1/4-inhibitors-1) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Mar 4, 2021 10:15:10 PM 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/therapeutic-potential-of-nadph-oxidase-1/4-inhibitors-1#comments-listing) Tags: [Articles & Whitepapers](https://news.cyprotex.com/sciencepool/tag/articles-whitepapers), [In vivo Pharmacology](https://news.cyprotex.com/sciencepool/tag/in-vivo-pharmacology), [Immunology & Inflammation](https://news.cyprotex.com/sciencepool/tag/immunology-inflammation) ## [Structure-Based Design of Tricyclic NF-κB Inducing Kinase Inhibitors](https://news.cyprotex.com/sciencepool/structure-based-design-of-tricyclic-nf-κb-inducing-kinase-inhibitors) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Mar 4, 2021 10:09:14 PM 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/structure-based-design-of-tricyclic-nf-κb-inducing-kinase-inhibitors#comments-listing) Tags: [Medicinal Chemistry](https://news.cyprotex.com/sciencepool/tag/medicinal-chemistry), [Articles & Whitepapers](https://news.cyprotex.com/sciencepool/tag/articles-whitepapers), [Immunology & Inflammation](https://news.cyprotex.com/sciencepool/tag/immunology-inflammation) ## [Thermodynamic Profiling of Inhibitors of Nrf2:Keap1 Interactions](https://news.cyprotex.com/sciencepool/thermodynamic-profiling-of-inhibitors-of-nrf2keap1-interactions) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Mar 4, 2021 9:51:30 PM 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/thermodynamic-profiling-of-inhibitors-of-nrf2keap1-interactions#comments-listing) Tags: [Articles & Whitepapers](https://news.cyprotex.com/sciencepool/tag/articles-whitepapers), [In vitro Biology](https://news.cyprotex.com/sciencepool/tag/in-vitro-biology), [Immunology & Inflammation](https://news.cyprotex.com/sciencepool/tag/immunology-inflammation) [All posts](https://news.cyprotex.com/sciencepool/all) [Next](https://news.cyprotex.com/sciencepool/tag/immunology-inflammation/page/2)