| Articles & Whitepapers (8)

Mutant huntingtin (mHTT) forms protein aggregates characteristic of Huntington's Disease pathology.

In this publication, we focus on:

a background to Huntington's Disease including the mutant huntingtin gene (mHTT)
a discussion of the benefits of sensitive biomarkers to monitor disease progression
the discovery of an mHTT aggregate-specific PET ligand suitable for live brain imaging

Huntington's Disease is caused a mutation in the huntingtin (mHTT) gene which codes for the huntingtin (HTT) protein.

In this publication, we focus on:

a background to link between Huntington's Disease and the mutant huntingtin gene (mHTT)
the development of PET tracers for imaging mHTT aggregates
characterisation of these PET tracers including pharmacological investigation of their binding affinities and selectivity

The ‘core’ metabolome of the Bacteroidetes genus Chitinophaga was recently discovered to consist of only seven metabolites. A structural relationship in terms of shared lipid moieties among four of them was postulated. Here, structure elucidation and characterization via ultra-high resolution mass spectrometry (UHR-MS) and nuclear magnetic resonance (NMR) spectroscopy of those four lipids (two lipoamino acids (LAAs), two lysophosphatidylethanolamines (LPEs)), as well as several other undescribed LAAs and N-acyl amino acids (NAAAs), identified during isolation were carried out.

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The need for antimalarial drugs is urgent in the face of growing resistance to existing therapies. Murithi et al. characterized MMV688533, an acylguanidine identified from compounds inhibiting known human drug targets that were screened for activity against Plasmodium falciparum

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Read Werner Lanthaler's commentary on 'The Data-Driven Autobahn to Cures' published in MedNous (April 2021) to learn about Evotec's new business model.

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Science Pool

Development of Potential PET Ligand for Imaging Mutant Huntingtin Aggregates

Pharmacological Characterization of Mutant Huntingtin Aggregate-Directed PET Imaging Tracer Candidates

Novel Glycerophospholipid, Lipo- and N-acyl Amino Acids from Bacteroidetes: Isolation, Structure Elucidation and Bioactivity

The Antimalarial MMV688533 provides Potential for Single-dose Cures with a High Barrier to Plasmodium Falciparum Parasite Resistance

The Tuberculosis Drug Accelerator: What have we Learned?

How to go from API to PAI

Potent and Selective Agonists of Human TRPM5

The Data-Driven Autobahn to Cures - Werner Lanthaler

Novel Bioengineered Peptide for Treating MDR Gram Negative Bacteria

Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium Tuberculosis