Science Pool

Our popular, easy-to-follow guide: 'DDI Regulatory Guidance' is now on its 3rd edition.

Read about:

• an easy to follow summary and comparison of the latest DDI guidance from the FDA and the EMA
• a focus on reaction phenotyping, cytochrome P450 inhibition, cytochrome P450 induction, drug transporter substrate studies and drug transporter inhibition
• an overview of the regulatory methods and interpretation of data

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Our popular, easy-to-follow guide: 'Mechanisms of Drug-induced Toxicity' is available to read online.

Read about:

• an overview of the different mechanisms of toxicity including:
  
  • mitochondrial toxicity
  • reactive oxygen species (ROS) and oxidative stress
  • reactive metabolite formation
  • cell cycle mediated toxicity
  • apoptosis
  • genotoxic and non-genotoxic carcinogens
  • phospholipidosis
  • steatosis
  • cholestasis
  • cardiac ion channel effects and hypertrophy
• an assessment of the current in vitro methods available for determining mechanistic toxicology 
• key references and further reading related to the topic

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