In vitro 3D microtissue models are transforming our understanding of cardiotoxicity.
In this poster, we focus on:
- the use of a 3D cardiac triculture model consisting of iPSC-derived cardiomyocytes, cardiovascular endothelial cells and cardiac fibroblasts in cardiotoxicity prediction
- the detection of functional and structural mechanisms of cardiotoxicity
- calcium flux as a sensitive detection method for cardiac contraction as well as microtissue area for identifying cardiac hypertrophy
- HCS detection of cell health markers such as mitochondrial function, calcium homeostasis and nuclei/DNA structure
Read our poster to learn more about our research!
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Download this fact sheet to learn more about our mitochondrial respiratory complex assay using permeabilised cells including:
- Background information
- Assay details and protocol summary
- Data generated in the mitochondrial respiratory complex assay
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Download this fact sheet to learn more about our drug induced phospholipidosis and steatosis assay including:
- Background information
- Assay details and protocol summary
- Data generated in the phospholipidosis and steatosis assay
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Download this fact sheet to learn more about the neurite outgrowth assay including:
- Background information
- Assay details and protocol summary
- Data generated in the neurite outgrowth assay
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Download this fact sheet to learn more about our mitochondrial biogenesis assay including:
- Background information
- Assay details and protocol summary
- Data generated in the mitochondrial biogenesis assay
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Download this fact sheet to learn more about our lysosomal trapping (Lysosomotropism) assay including:
- Background information
- Assay details and protocol summary
- Data generated in the lysosomal trapping assay
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Download this fact sheet to learn more about the in vitro comet assay including:
- Background information
- Assay details and protocol summary
- Data generated in the in vitro comet assay
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Download this fact sheet to learn more about our in vitro androgen receptor modulation assay including:
- Background information
- Assay details and protocol summary
- Data generated in the androgen receptor modulation assay
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Download this fact sheet to learn more about our CellCiphr® Premier high content toxicity assay including:
- Background information
- Assay details and protocol summary
- Data generated in the CellCiphr® Premier toxicity assay
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Download this fact sheet to learn more about our hERG channel inhibition assay including:
- Background information
- Assay details and protocol summary
- Data generated in the hERG channel inhibition assay
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