Understand if your investigational drug is a potential victim (object) of transporter-mediated drug-drug interactions by evaluating if it is a substrate of drug transporters.
Read our fact sheet to learn more about our transporter substrate identification service.
Tags: Fact Sheets, ADME/DMPK, IND Enabling Studies/Preclinical Development, Cyprotex
Learn more about how Cyprotex can support you in the design, implementation and interpretation of drug-drug interaction (DDI) studies according to regulatory guidance including the ICH M12 harmonized guideline.
Read our DDI fact sheet to find out more.
Tags: Fact Sheets, ADME/DMPK, IND Enabling Studies/Preclinical Development
Learn more about how Cyprotex can support you in discovery bioanalysis for small molecules and biotherapeutics (including peptides, oligonucleotides and protein degraders).
Read our fact sheet to find out more about our non-regulatory bioanalysis service.
Tags: Drug Discovery, Fact Sheets, ADME/DMPK, Cyprotex
Learn more about how Cyprotex can support you in understanding the metabolism of your compounds by identifying which metabolites are formed during in vitro and in vivo studies.
Read our fact sheet to learn more about our metabolite profiling and identification service.
Tags: Fact Sheets, ADME/DMPK, IND Enabling Studies/Preclinical Development, Cyprotex
Drug-induced liver injury (DILI) is a major cause of drug attrition - responsible for 18% of drug withdrawals from the market.
Learn more about how Cyprotex can support you in understanding potential DILI risk of your test article.
Tags: Fact Sheets, Toxicology & Safety, Cyprotex
Cardiotoxicity is a major cause of drug attrition accounting for 45% of all drugs taken off the market between 1994 and 2006.
Learn more about how Cyprotex can support you in understanding the potential risk of cardiotoxicity of your test article.
Tags: Fact Sheets, Toxicology & Safety, Cyprotex
Cell painting analyses phenotypic changes in cells following dosing with test articles. It can be used to assess potential toxicity risks.
Read our fact sheet to learn more about how Cyprotex can support you in understanding the potential risk of toxicity using cell painting.
Tags: Fact Sheets, Toxicology & Safety, Cyprotex
Tags: Material Sciences, Fact Sheets
Download this fact sheet to learn more about the PXR, AhR and CAR3 nuclear receptor activation assay including:
Tags: Fact Sheets, ADME/DMPK
Download this fact sheet to learn more about how Cyprotex can support you in the design and implementation of high throughput ADME and physicochemical profiling studies.
We offer a rapid flexible service delivering high quality data for a comprehensive range of assays to support your drug discovery project.
Tags: Fact Sheets, ADME/DMPK