Science Pool

Our factsheet gives an overview of Evotec Modena's capabilities. Download it now to discover more.

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Bioinformatics supporting Infectious Disease: Creating knowledge for efficient discovery and development of better medicines.​

Pathogen functional genomics analyses for unbiased, multidimensional small molecule effect characterisation (RNA-, DNA-seq analyses to characterise pathogen genome and transcriptome)

Genome assembly and annotation with a focus on resistance and virulence (Illumina, ONT, hybrid)

• Short- (SNP, short indels) and long-range (insertion, deletion, inversion, translocation, duplication) variant analysis associated with resistance (Illumina, ONT)
• Bacterial genome wide association study (GWAS)
• Transcriptome analysis (RNAseq) and functional interpretation
• Bacterial population sequencing and variant characterisation (PoolSeq)
• Molecular phylogeny
• Network analysis (enrichment analysis, pathway mapping)

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Learn more about fully integrated development at Evotec.

Evotec is a fully-integrated drug discovery and development partner, providing a comprehensive source of high quality scientific solutions with consultant-level expertise to our partners, which includes fully integrated research and development as well as clinical development through to Proof of Concept.

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Learn more about our activities for Deep Proteomics at Scale to Drive Biomarker Discovery.

To further boost Evotec’s high-throughput proteomics platform we have implemented the Proteograph™ platform from Seer, which enables automated and unbiased nanoparticle based protein enrichment for maximal proteomic insights.

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INDiGO is the fastest and most efficient platform to bring a program from candidate selection through IND and beyond.

Once your clinical candidate is selected, this fully-integrated clinical-enabling package provides inter-disciplinary coordination of all aspects of drug development, conducted and managed by a dedicated Evotec team, and usually at a single Evotec site.

Key features:

•  Accelerating your drug discovery and research programs through interdisciplinary integration and expert coordination of all activities “under one roof”
• Industry-leading timelines, taking your program from the selection of an optimal clinical candidate to regulatory submission typically in less than 52 weeks
• Expert management by experienced, dedicated project managers and drug development professionals
• Seamless knowledge transfer across disciplines, maximizing the quality and efficiency of the overall development package
• Custom-designed, flexible development plans that allow for real-time adjustments and adaptability to unforeseeable scientific outcomes
• Excellence in project governance, performance review and issue escalation management

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Download this fact sheet to learn more about cytochrome P450 (CYP) induction including:

• Background information
• Assay details and protocol summary
• Data generated in the CYP induction assay

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Download this fact sheet to learn more about cytochrome P450 (CYP) relative induction score (RIS) including:

• Background information for the CYP induction RIS method
• Assay details and protocol summary for the CYP induction RIS method
• Data generated in the CYP induction RIS assay

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Download this fact sheet to learn more about hepatocyte stability including:

• Background information
• Assay details and protocol summary
• Data generated in the hepatocyte stability assay

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Learn more about the use of transcriptomics in safety prediction including:

• the challenges in translation from animals to humans, and how human cell-based models are now being routinely used in toxicology
• how transcriptomic analysis is showing promise in enhancing safety prediction and providing additional mechanistic information
• an overview of how Cyprotex, and parent company Evotec, are offering a fully customised end-to-end in vitro transcriptomics service using the latest next generation sequencing technology (RNA-seq) and a leading bioinformatics platform
• the use of sophisticated machine learning and artificial intelligence to interpret the large and complex datasets

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Download this fact sheet to learn more about formulating your way to successful toxicology studies including:

• Early formulation
• Material science - solid development
• DMPK
• In vitro, in vivo, and in silico models

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