--- title: | Toxicology & Safety (5) description: Toxicology & Safety | (5) --- [![Cyprotex | The Leading ADME-Tox Specialist](https://news.cyprotex.com/hs-fs/hubfs/cyprotex%20logo.png?width=224&height=62&name=cyprotex%20logo.png "Cyprotex | The Leading ADME-Tox Specialist")](https://www.cyprotex.com/) # Science Pool ## [Cardiotox Screen Fact Sheet](https://news.cyprotex.com/sciencepool/cardiotox-screen-fact-sheet) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Aug 6, 2021 6:12:43 PM Learn more about the Cardiotox Screen for assessment of structural and functional cardiotoxicity including: - background information - details and protocol summary - data generated in the Cardiotox Screen [DOWNLOAD](https://news.cyprotex.com/hubfs/Sciencepool/Fact%20sheets/Cyprotex%20Facts%20Sheets/cyprotex-cardiotox-screen-fact-sheet.pdf) 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/cardiotox-screen-fact-sheet#comments-listing) Tags: [Fact Sheets](https://news.cyprotex.com/sciencepool/tag/fact-sheets), [Toxicology & Safety](https://news.cyprotex.com/sciencepool/tag/toxicology-safety) ## [Transcriptomics - The Future of Toxicology Prediction](https://news.cyprotex.com/sciencepool/transcriptomics-the-future-of-tox-prediction) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Aug 6, 2021 4:23:56 PM 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/transcriptomics-the-future-of-tox-prediction#comments-listing) Tags: [Videos & Webinars](https://news.cyprotex.com/sciencepool/tag/videos-webinars), [Toxicology & Safety](https://news.cyprotex.com/sciencepool/tag/toxicology-safety) ## [Fast and Easy In Vitro Tox in PanHunter](https://news.cyprotex.com/sciencepool/panhunter-in-vitro-tox) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Jul 5, 2021 1:58:28 PM 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/panhunter-in-vitro-tox#comments-listing) Tags: [Videos & Webinars](https://news.cyprotex.com/sciencepool/tag/videos-webinars), [In vitro Biology](https://news.cyprotex.com/sciencepool/tag/in-vitro-biology), [Toxicology & Safety](https://news.cyprotex.com/sciencepool/tag/toxicology-safety) ## [Human iPSC-Derived Mixed CNS Cells Fact Sheet](https://news.cyprotex.com/sciencepool/human-ipsc-derived-mixed-cns-cells-fact-sheet) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Jun 21, 2021 12:01:21 PM Learn more about Human iPSC-Derived Mixed CNS Cells and their advantages including: - Highly physiological neural networks - Long term synchronous network activity - Suitable as seizure liability mode [DOWNLOAD](https://news.cyprotex.com/hubfs/Sciencepool/Fact%20sheets/Evotec%20Fact%20Sheets/human-iPSC-derived-mixed-CNS-cells-fact-sheet.pdf) 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/human-ipsc-derived-mixed-cns-cells-fact-sheet#comments-listing) Tags: [Neuroscience](https://news.cyprotex.com/sciencepool/tag/neuroscience), [Fact Sheets](https://news.cyprotex.com/sciencepool/tag/fact-sheets), [Hit & Target ID/Validation](https://news.cyprotex.com/sciencepool/tag/hit-target-id-validation), [Biologics](https://news.cyprotex.com/sciencepool/tag/biologics), [In vitro Biology](https://news.cyprotex.com/sciencepool/tag/in-vitro-biology), [Toxicology & Safety](https://news.cyprotex.com/sciencepool/tag/toxicology-safety) ## [Human iPSC-Derived Cardiomyocyte Fact Sheet](https://news.cyprotex.com/sciencepool/human-ipsc-derived-cardiomyocyte-fact-sheet) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Jun 21, 2021 12:00:42 PM Learn more about the advantages of human iPSC-derived cardiomyocytes including: - Predictive and physiological cell model - Applicable for drug development, preclinical research, and cardiac safety assessment - Quantity, consistency and efficiency for HTS [DOWNLOAD](https://news.cyprotex.com/hubfs/Sciencepool/Fact%20sheets/Evotec%20Fact%20Sheets/human-iPSC-derived-cardiomyocytes-fact-sheet.pdf) 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/human-ipsc-derived-cardiomyocyte-fact-sheet#comments-listing) Tags: [Fact Sheets](https://news.cyprotex.com/sciencepool/tag/fact-sheets), [Hit & Target ID/Validation](https://news.cyprotex.com/sciencepool/tag/hit-target-id-validation), [Biologics](https://news.cyprotex.com/sciencepool/tag/biologics), [In vitro Biology](https://news.cyprotex.com/sciencepool/tag/in-vitro-biology), [Toxicology & Safety](https://news.cyprotex.com/sciencepool/tag/toxicology-safety) ## [In Vitro iPSC Research Services Fact Sheet](https://news.cyprotex.com/sciencepool/in-vitro-ipsc-research-services-fact-sheet) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Jun 21, 2021 11:59:53 AM Learn more about in Vitro iPSC research services at Evotec including: - Robust differentiation protocols or adaptation of client protocols - High-quality production of iPSC-derived cells at large scale - Disease-relevant phenotypic read-outs for exploratory research and compound profiling/HTS - Proprietary iPSC patent portfolio in tissue and disease modeling [DOWNLOAD](https://news.cyprotex.com/hubfs/Evotec-in-vitro-ipsc-research-services-factsheet.pdf) 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/in-vitro-ipsc-research-services-fact-sheet#comments-listing) Tags: [Fact Sheets](https://news.cyprotex.com/sciencepool/tag/fact-sheets), [Hit & Target ID/Validation](https://news.cyprotex.com/sciencepool/tag/hit-target-id-validation), [Biologics](https://news.cyprotex.com/sciencepool/tag/biologics), [In vitro Biology](https://news.cyprotex.com/sciencepool/tag/in-vitro-biology), [Toxicology & Safety](https://news.cyprotex.com/sciencepool/tag/toxicology-safety) ## [Dual Detection of Functional and Structural Cardiotoxicity](https://news.cyprotex.com/sciencepool/dual-detection-of-functional-and-structural-cardiotoxicity) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Jun 16, 2021 10:39:39 AM Cardiotoxic drugs can display acute alteration in the mechanical function of the myocardium (functional changes) or morphological damage to cardiomyocytes and/or loss of viability (structural changes).    In this poster, we focus on: - the detection of functional cardiomyocyte changes through monitoring of calcium transients using human iPSC-derived cardiomyocytes - the analysis of structural morphology using high content imaging (calcium homeostasis and mitochondrial function) as well as cellular ATP in human iPSC-derived cardiomyocytes - the presentation of a strategy for understanding cardiotoxicity risk for novel compounds enabling *in vitro* to *in vivo* translation at an early stage in preclinical screening. Read our poster to learn more about our research! [LEARN MORE](https://news.cyprotex.com/hubfs/Sciencepool/Posters/Cyprotex%20posters/dual-detection-functional-structural-cardiotoxicity-sot2021.pdf)   0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/dual-detection-of-functional-and-structural-cardiotoxicity#comments-listing) Tags: [Posters](https://news.cyprotex.com/sciencepool/tag/posters), [IND Enabling Studies/Preclinical Development](https://news.cyprotex.com/sciencepool/tag/ind-enabling-studies-preclinical-development), [Toxicology & Safety](https://news.cyprotex.com/sciencepool/tag/toxicology-safety) ## [Improving the Prediction of Mitochondrial Toxicity](https://news.cyprotex.com/sciencepool/improving-the-prediction-mitochondrial-toxicity) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Mar 7, 2021 1:57:23 PM Drug-induced mitochondrial dysfunction has been associated with organ toxicity and drug withdrawal. Highly specific and sensitive *in vitro* assays have been developed to predict mitochondrial dysfunction. In this publication, we focus on: - a background to mitochondrial toxicity - a comparison of the Glu/Gal mitochondrial assay with the Seahorse assay for the prediction of mitochondrial toxicity - how the Seahorse assay provides a mechanistic understanding of mitochondrial toxicity Read our publication to learn more! [LEARN MORE](https://news.cyprotex.com/hubfs/Sciencepool/Articles,%20DDups%20and%20Whitepapers/combined-prediction-mitochondrial-toxicants-publication.pdf) 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/improving-the-prediction-mitochondrial-toxicity#comments-listing) Tags: [Articles & Whitepapers](https://news.cyprotex.com/sciencepool/tag/articles-whitepapers), [Toxicology & Safety](https://news.cyprotex.com/sciencepool/tag/toxicology-safety) ## [Strategies to Minimise the Risk of DILI](https://news.cyprotex.com/sciencepool/strategies-to-minimise-risk-dili) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Mar 7, 2021 1:24:04 PM Drug-induced liver injury (DILI) is a leading cause of drug failure due to poor translation between traditional preclinical animal models and human clinical outcome. More sophisticated human *in vitro* cell-based models with multiparametric endpoints are now being developed to improve DILI prediction. In this review article, we focus on: - the evolution of the strategies adopted to improve human hepatotoxicity prediction in drug discovery - how companies are addressing translational challenges using human relevant cell-based models - a further insight into the key role of human exposure and hepatic drug uptake transporters (e.g., OATPs, OAT2) Read our publication to learn more! [LEARN MORE](https://news.cyprotex.com/hubfs/Sciencepool/Articles,%20DDups%20and%20Whitepapers/strategies-to-minimise-the-risk-of-human-dili-publication.pdf) 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/strategies-to-minimise-risk-dili#comments-listing) Tags: [Articles & Whitepapers](https://news.cyprotex.com/sciencepool/tag/articles-whitepapers), [Toxicology & Safety](https://news.cyprotex.com/sciencepool/tag/toxicology-safety) ## [The Future of MEA in Early Toxicology Assessment](https://news.cyprotex.com/sciencepool/the-future-of-mea-in-early-toxicology-assessment) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Mar 7, 2021 1:11:12 PM It is almost 50 years since MEA was first developed, however, the power of this technology in toxicology testing has only just been realised due to the introduction of the multi-well MEA allowing for its utility in high throughput analysis. In this whitepaper, we focus on: - the current challenges within the pharmaceutical industry in terms of toxicology prediction - how companies are addressing these challenges using human relevant cell-based models - an in-depth evaluation of microelectrode array (MEA) and its key role in *in vitro* cardiotoxicity and neurotoxicity toxicology testing Read our whitepaper to learn more! [LEARN MORE](https://news.cyprotex.com/hubfs/Sciencepool/Articles,%20DDups%20and%20Whitepapers/future-mea-in-toxicology-whitepaper.pdf) 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/the-future-of-mea-in-early-toxicology-assessment#comments-listing) Tags: [Neuroscience](https://news.cyprotex.com/sciencepool/tag/neuroscience), [Articles & Whitepapers](https://news.cyprotex.com/sciencepool/tag/articles-whitepapers), [Toxicology & Safety](https://news.cyprotex.com/sciencepool/tag/toxicology-safety) [Previous](https://news.cyprotex.com/sciencepool/tag/toxicology-safety/page/4) [All posts](https://news.cyprotex.com/sciencepool/all) [Next](https://news.cyprotex.com/sciencepool/tag/toxicology-safety/page/6)