| In vivo Pharmacology (2)

Development of Potential PET Ligand for Imaging Mutant Huntingtin Aggregates

Posted by Evotec on Sep 13, 2021 8:06:10 PM

Mutant huntingtin (mHTT) forms protein aggregates characteristic of Huntington's Disease pathology.

In this publication, we focus on:

a background to Huntington's Disease including the mutant huntingtin gene (mHTT)
a discussion of the benefits of sensitive biomarkers to monitor disease progression
the discovery of an mHTT aggregate-specific PET ligand suitable for live brain imaging

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Tags: Neuroscience, Articles & Whitepapers, In vivo Pharmacology

Pharmacological Characterization of Mutant Huntingtin Aggregate-Directed PET Imaging Tracer Candidates

Posted by Evotec on Sep 13, 2021 8:03:47 PM

Huntington's Disease is caused a mutation in the huntingtin (mHTT) gene which codes for the huntingtin (HTT) protein.

In this publication, we focus on:

a background to link between Huntington's Disease and the mutant huntingtin gene (mHTT)
the development of PET tracers for imaging mHTT aggregates
characterisation of these PET tracers including pharmacological investigation of their binding affinities and selectivity

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Tags: Neuroscience, Articles & Whitepapers, In vitro Biology, In vivo Pharmacology

Potent and Selective Agonists of Human TRPM5

Posted by Evotec on Jun 17, 2021 5:49:12 PM

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Tags: Articles & Whitepapers, Hit & Target ID/Validation, In vivo Pharmacology

Hydroxyproline Quantitation in Bleomycin-induced Lung Fibrosis Model

Posted by Evotec on Apr 22, 2021 9:22:39 AM

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Tags: Respiratory, Posters, In vivo Pharmacology

Inhibition of NF-kB Inducing Kinase in IFNα-accelerated Lupus Nephritis

Posted by Evotec on Mar 5, 2021 5:36:55 PM

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Tags: Kidney diseases, Articles & Whitepapers, In vivo Pharmacology, Immunology & Inflammation, Metabolic Disease & Complications

Design of Clinical Trials in Patients with Decompensated Cirrhosis

Posted by Evotec on Mar 4, 2021 10:53:37 PM

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Tags: Articles & Whitepapers, In vivo Pharmacology

ABHD11: A New Diacylglycerol Lipase Involved in Weight Gain Regulation

Posted by Evotec on Mar 4, 2021 10:52:37 PM

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Tags: Articles & Whitepapers, In vivo Pharmacology, Metabolic Disease & Complications

Therapeutic Potential of NADPH Oxidase 1/4 Inhibitors

Posted by Evotec on Mar 4, 2021 10:15:10 PM

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Tags: Articles & Whitepapers, In vivo Pharmacology, Immunology & Inflammation

Neurturin and a GLP-1 Analogue Synergistically Alleviate Diabetes in Zucker Diabetic Fatty Rats

Posted by Evotec on Mar 4, 2021 10:13:07 PM

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Tags: Articles & Whitepapers, In vivo Pharmacology, Metabolic Disease & Complications

Restoration of Electrophysiological Alterations in Mouse Models of Huntington's Disease

Posted by Evotec on Mar 4, 2021 9:43:40 PM

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Tags: Neuroscience, Articles & Whitepapers, In vivo Pharmacology

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