Science Pool

3D Cell Models DDup #12

Posted by Evotec on Mar 10, 2022 11:38:33 AM

The 12th edition of our Drug Discovery Update (DDup) provides insights into exciting new developments in 3D cell models including microtissues, organoids and organ-on-a-chip technology.

In this edition, it covers:

  • an introduction to 3D cellular models
    • the need for better models to improve translation from in vitro to in vivo
    • the relevance of 3D cellular models to kidney disease modelling and drug induced toxicity prediction
  • an overview of Evotec's 3D in vitro platforms
    • glomerulus-on-a-chip to study kidney disease
    • kidney organoids to study polycystic kidney disease
    • organ microtissues to predict drug-induced toxicity
  • interviews with experts Dr Christodoulos Xinaris, Dr Reiner Class, Dr Magali Ferro and Dr Stephanie Ryder

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Tags: Kidney diseases, Articles & Whitepapers, Toxicology & Safety, Metabolic Disease & Complications

Automated Utrophin Imaging for Duchenne Muscular Dystrophy

Posted by Evotec on Mar 11, 2021 8:27:34 PM

Tags: Posters, Metabolic Disease & Complications, Rare Diseases

Novel Small Molecule Treatment Options for FSHD

Posted by Evotec on Mar 11, 2021 8:26:35 PM

Tags: Posters, Metabolic Disease & Complications, Rare Diseases

AhR as a Molecular Target of the Utrophin Modulator Ezutromid

Posted by Evotec on Mar 11, 2021 8:21:57 PM

Tags: Articles & Whitepapers, Hit & Target ID/Validation, Proteomics, Metabolomics & Biomarkers, Metabolic Disease & Complications, Rare Diseases

Metabolic and Kidney Disease Long Term Vision Fact Sheet

Posted by Evotec on Mar 8, 2021 10:30:59 PM

Learn more about Evotec's long term vision in Kidney Disease therapeutics including:

  • Molecular patient databases
  • Patient derived disease models
  • Molecular profiles turned biomarkers
  • Evotec's footprint in chronic kidney disease
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Tags: Kidney diseases, Fact Sheets, Metabolic Disease & Complications

Inhibition of NF-kB Inducing Kinase in IFNα-accelerated Lupus Nephritis

Posted by Evotec on Mar 5, 2021 5:36:55 PM

Tags: Kidney diseases, Articles & Whitepapers, In vivo Pharmacology, Immunology & Inflammation, Metabolic Disease & Complications

ABHD11: A New Diacylglycerol Lipase Involved in Weight Gain Regulation

Posted by Evotec on Mar 4, 2021 10:52:37 PM

Tags: Articles & Whitepapers, In vivo Pharmacology, Metabolic Disease & Complications

Identifying Regulators of Kidney Fibrosis

Posted by Evotec on Mar 4, 2021 10:51:10 PM

Tags: Kidney diseases, Articles & Whitepapers, Metabolic Disease & Complications

Neurturin and a GLP-1 Analogue Synergistically Alleviate Diabetes in Zucker Diabetic Fatty Rats

Posted by Evotec on Mar 4, 2021 10:13:07 PM

Tags: Articles & Whitepapers, In vivo Pharmacology, Metabolic Disease & Complications

Drug Discovery Insight: Evotec and Bayer Partner to Fight Kidney Diseases

Posted by Evotec on Mar 4, 2021 9:18:00 PM

Tags: Kidney diseases, Articles & Whitepapers, Metabolic Disease & Complications