--- title: | Respiratory description: Respiratory | --- [![Cyprotex | The Leading ADME-Tox Specialist](https://news.cyprotex.com/hs-fs/hubfs/cyprotex%20logo.png?width=224&height=62&name=cyprotex%20logo.png "Cyprotex | The Leading ADME-Tox Specialist")](https://www.cyprotex.com/) # Science Pool ## [Mouse Pneumonia Model by Acinetobacter baumannii Multidrug Resistant Strains](https://news.cyprotex.com/sciencepool/mouse-pneumonia-model-by-acinetobacterbaumannii-multidrug-resistant-strains) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Dec 21, 2021 2:49:52 PM Pneumonia induced by multidrug resistant (MDR) *Acinetobacter baumannii* strains is among the most common and deadly forms of healthcare acquired infections. Animal models play a critical role during the preclinical assessment of novel therapeutic approaches, however, only a self-limiting pneumonia with no or limited local bacterial replication is frequently obtained when MDR *A. baumannii* is the pathogen. To strengthen and characterise a sustained lung infection model, in this publication, we focus on: - the ability of intranasal inoculation, intratracheal instillation and oropharyngeal aspiration methods of administration of the bacterial challenge to induce a robust pneumonia in mice - the characterisation of the infection model obtained after intratracheal instillation and oropharyngeal aspiration in terms of histopathological examination of pulmonary lesions, biomarkers of inflammation and leukocytes cells infiltration after treatment with either vehicle or with the antibiotic tigecycline efficacious into reducing lung bacterial load. [LEARN MORE](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0260627) 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/mouse-pneumonia-model-by-acinetobacterbaumannii-multidrug-resistant-strains#comments-listing) Tags: [Respiratory](https://news.cyprotex.com/sciencepool/tag/respiratory), [Articles & Whitepapers](https://news.cyprotex.com/sciencepool/tag/articles-whitepapers), [In vivo Pharmacology](https://news.cyprotex.com/sciencepool/tag/in-vivo-pharmacology) ## [Hydroxyproline Quantitation in Bleomycin-induced Lung Fibrosis Model](https://news.cyprotex.com/sciencepool/hydroxyproline-quantitation-in-bleomycin-induced-lung-fibrosis-model) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Apr 22, 2021 9:22:39 AM 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/hydroxyproline-quantitation-in-bleomycin-induced-lung-fibrosis-model#comments-listing) Tags: [Respiratory](https://news.cyprotex.com/sciencepool/tag/respiratory), [Posters](https://news.cyprotex.com/sciencepool/tag/posters), [In vivo Pharmacology](https://news.cyprotex.com/sciencepool/tag/in-vivo-pharmacology) ## [Inhalation Drug Development Fact Sheet](https://news.cyprotex.com/sciencepool/inhalation-drug-development-fact-sheet) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Mar 29, 2021 8:55:41 PM Learn more about inhalation drug development at Evotec including: - Integrated and stand-alone development plans tailored to your project - Formulation development of dry powders and liquids designed to meet a quality target product profile (QTPP) with consideration of final commercial process - Inhaled analytics, API, material science, cGMP maufacturing and quality assurance processes [DOWNLOAD](https://news.cyprotex.com/hubfs/Sciencepool/Fact%20sheets/Evotec%20Fact%20Sheets/inhalation-capabilities-fact-sheet.pdf)   0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/inhalation-drug-development-fact-sheet#comments-listing) Tags: [Respiratory](https://news.cyprotex.com/sciencepool/tag/respiratory), [Fact Sheets](https://news.cyprotex.com/sciencepool/tag/fact-sheets), [Formulation & CMC](https://news.cyprotex.com/sciencepool/tag/formulation-cmc) ## [Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium Tuberculosis](https://news.cyprotex.com/sciencepool/bactericidal-disruption-of-magnesium-metallostasis-in-mycobacterium-tuberculosis) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Mar 22, 2021 2:39:03 PM 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/bactericidal-disruption-of-magnesium-metallostasis-in-mycobacterium-tuberculosis#comments-listing) Tags: [Medicinal Chemistry](https://news.cyprotex.com/sciencepool/tag/medicinal-chemistry), [Respiratory](https://news.cyprotex.com/sciencepool/tag/respiratory), [Articles & Whitepapers](https://news.cyprotex.com/sciencepool/tag/articles-whitepapers), [In vitro Biology](https://news.cyprotex.com/sciencepool/tag/in-vitro-biology), [Anti-Infectives](https://news.cyprotex.com/sciencepool/tag/anti-infectives) ## [Pyrithione-Containing Cephalosporins in Mycobacterium Tuberculosis](https://news.cyprotex.com/sciencepool/pyrithione-containing-cephalosporins-in-mycobacterium-tuberculosis) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Mar 22, 2021 2:38:06 PM 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/pyrithione-containing-cephalosporins-in-mycobacterium-tuberculosis#comments-listing) Tags: [Medicinal Chemistry](https://news.cyprotex.com/sciencepool/tag/medicinal-chemistry), [Respiratory](https://news.cyprotex.com/sciencepool/tag/respiratory), [Articles & Whitepapers](https://news.cyprotex.com/sciencepool/tag/articles-whitepapers), [In vitro Biology](https://news.cyprotex.com/sciencepool/tag/in-vitro-biology), [Anti-Infectives](https://news.cyprotex.com/sciencepool/tag/anti-infectives) ## [Design, Synthesis & SAR of IL2 Inducible T Cell Kinase Inhibitors](https://news.cyprotex.com/sciencepool/design-synthesis-sar-of-il2-inducible-t-cell-kinase-inhibitors) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Mar 5, 2021 11:54:08 AM 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/design-synthesis-sar-of-il2-inducible-t-cell-kinase-inhibitors#comments-listing) Tags: [Medicinal Chemistry](https://news.cyprotex.com/sciencepool/tag/medicinal-chemistry), [Respiratory](https://news.cyprotex.com/sciencepool/tag/respiratory), [Articles & Whitepapers](https://news.cyprotex.com/sciencepool/tag/articles-whitepapers), [Immunology & Inflammation](https://news.cyprotex.com/sciencepool/tag/immunology-inflammation) ## [Lead Optimization of Novel Interleukin-2 Inducible T-Cell Kinase (ITK) Inhibitors](https://news.cyprotex.com/sciencepool/lead-optimization-of-novel-interleukin-2-inducible-t-cell-kinase-itk-inhibitors) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Mar 4, 2021 9:46:18 PM 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/lead-optimization-of-novel-interleukin-2-inducible-t-cell-kinase-itk-inhibitors#comments-listing) Tags: [Medicinal Chemistry](https://news.cyprotex.com/sciencepool/tag/medicinal-chemistry), [Respiratory](https://news.cyprotex.com/sciencepool/tag/respiratory), [Articles & Whitepapers](https://news.cyprotex.com/sciencepool/tag/articles-whitepapers), [Immunology & Inflammation](https://news.cyprotex.com/sciencepool/tag/immunology-inflammation) ## [Drug Discovery Insight: Evotec's Alliance with Bayer to Fight Chronic Cough](https://news.cyprotex.com/sciencepool/drug-discovery-insight-fighting-chronic-cough) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Mar 4, 2021 9:17:03 PM 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/drug-discovery-insight-fighting-chronic-cough#comments-listing) Tags: [Respiratory](https://news.cyprotex.com/sciencepool/tag/respiratory), [Articles & Whitepapers](https://news.cyprotex.com/sciencepool/tag/articles-whitepapers) ## [Effects of Theophylline and Budesonide on Asthma Inflammation Model](https://news.cyprotex.com/sciencepool/effects-of-theophylline-and-budesonide-on-asthma-inflammation-model-poster) Posted by [Evotec](https://news.cyprotex.com/sciencepool/author/evotec) on Feb 24, 2021 12:00:51 PM 0 Comments [Click here to read/write comments](https://news.cyprotex.com/sciencepool/effects-of-theophylline-and-budesonide-on-asthma-inflammation-model-poster#comments-listing) Tags: [Respiratory](https://news.cyprotex.com/sciencepool/tag/respiratory), [Posters](https://news.cyprotex.com/sciencepool/tag/posters), [In vivo Pharmacology](https://news.cyprotex.com/sciencepool/tag/in-vivo-pharmacology) [All posts](https://news.cyprotex.com/sciencepool/all)