Originally presented in Science Translational Medicine, this article co-written with Merck & Co. presents a set of bifunctional HIV therapies, dubbed targeted activator of cell kill (TACK) molecules, that were optimized for simultaneous antiviral activity and selective elimination of infected CD4+ T cells from HIV-1 patients.
Tags: Articles & Whitepapers, Structural Biology & Protein Science, Immunology & Inflammation
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, kills 1.5 to 1.7 million people every year. Macrophages are Mtb’s main host cells and their inflammatory response is an essential component of the host defense against Mtb. However, Mtb is able to circumvent the macrophages’ defenses by triggering an inappropriate inflammatory response. Understanding macrophage interactions with Mtb is crucial to develop strategies to control tuberculosis. The present study aims to determine the inflammatory response transcriptome and miRNome of human macrophages infected with the virulent H37Rv Mtb strain, to identify macrophage genetic networks specifically modulated by Mtb virulence.
Tags: Medicinal Chemistry, Articles & Whitepapers, In vitro Biology, Anti-Infectives, Immunology & Inflammation
Tags: Medicinal Chemistry, Evotec, Women's health, Immunology & Inflammation
Tags: Medicinal Chemistry, Women's health, Articles & Whitepapers, Hit & Target ID/Validation, Immunology & Inflammation
Tags: Medicinal Chemistry, Articles & Whitepapers, Immunology & Inflammation
Tags: Kidney diseases, Articles & Whitepapers, In vivo Pharmacology, Immunology & Inflammation, Metabolic Disease & Complications
Tags: Medicinal Chemistry, Respiratory, Articles & Whitepapers, Immunology & Inflammation
Tags: Articles & Whitepapers, Hit & Target ID/Validation, Immunology & Inflammation
Tags: Articles & Whitepapers, In vivo Pharmacology, Immunology & Inflammation
Tags: Medicinal Chemistry, Articles & Whitepapers, Immunology & Inflammation